16-JUN-2024 6:10

Lung-MAP ACCRUAL REPORT

  O
P
E
N
ACCR
GOAL
TOTAL
REGS.
REGS.
LAST
12
Month
REGS.
LAST
6
Month
REGS.
LAST
3
Month
REGS.
LAST
30
DAYS
REGS.
LAST
7
DAYS
DATE OF
FIRST
REG.
# of
ACT.
INSTs
# of
CURR
IRBs
LUNGMAP Screening Protocol Registrations
Total     3392 317 152 68 24 5 02/06/2019 413 177
Screened at PD     1209 78 36 13 6 1      
Pre-Screened prior to PD     2183 239 116 55 18 4      
ctDNA Specimen Submission     315 0 0 0 0 0      
Re-analysis Requests     448 108 45 21 5 2      
 
Sub-Study Assignments
LUNGMAP Sub-Study Assignments     1725 60 23 12 5 3      
Screened at PD     976 35 13 6 2 0      
Pre-Screened prior to PD     697 25 10 6 3 3      
After PD on a Lung_MAP Sub-Study     52 0 0 0 0 0      
 
Sub-Study Assignments (open studies only)
S1900E     238 40 14 8 3 2      
S1900G     19 17 6 2 1 0      
S1900K     3 3 3 2 1 1      
 
Sub-Study Registrations
LUNGMAP Sub-Study Registrations     481 29 10 4 1 0      
Initial sub-study registrations     469 29 10 4 1 0      
Subsequent sub-study registrations     12 0 0 0 0 0      
 
Patients Registered to a Sub-Study (open studies only)
S1900E: KRAS G12C: Sotorasib (AMG 510)   116 113 19 5 3 0 0 04/16/2021 312 126
Cohort 1: TP53 N   48 6 0 0 0 0      
Cohort 2: STK11 Y   27 8 4 3 0 0      
Cohort 3: All Others Y   38 5 1 0 0 0      
S1900G: EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu   66 12 10 5 1 1 0 05/05/2023 253 98
Capmatinib + Osimertinib + Ramucirumab Y   5 4 2 1 1 0      
Capmatinib + Osimertinib Y   7 6 3 0 0 0      
 

16-JUN-2024 6:10

Lung-MAP Open Studies with No Registrations

Study Registration/Phase Open Date # of
ACT.
INSTs
# of
CURR
IRBs
S1900K MET Exon 14: Tepotinib +/- Ramucirumab 1 Randomization 18-Dec-23 209 80