10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

THERAPEUTIC STUDIES ONLY (TXCA=Y)

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 1564 350 22% 1277 -286 1122 -442
ERLYTX 76 19 25% 69 -6 77 1
GI 479 44 9% 160 -318 184 -295
GU 450 78 17% 284 -165 371 -79
GYN 57 0 0% 0 -57 0 -57
LEUK 150 32 21% 116 -33 140 -10
LUNG 524 63 12% 229 -294 199 -325
LYMPH 172 109 63% 397 225 393 221
MELAN 55 0 0% 0 -55 180 125
MMYEL 147 30 20% 109 -37 113 -34
MULT 0 13   47 47 35 35
OTHER 0 17   62 62 51 51
PREV 0 0   0 0 0 0
SXQOL 0 0   0 0 2 2
Total 3674 755   2750 -917 2867 -807

10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

NON-THERAPEUTIC STUDIES ONLY (TXCA=N)

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 43 0 0% 0 -43 0 -43
CCD 0 57   208 208 141 141
ERLYTX 0 3   10 10 11 11
GU 0 6   21 21 6 6
LEUK 69 168 243% 613 544 616 547
LUNG 43 113 263% 412 369 366 323
LYMPH 53 1 2% 3 -49 1 -52
MMYEL 92 0 0% 0 -92 0 -92
OTHER 0 4   14 14 35 35
PEOLC 0 10   36 36 118 118
PREV 0 62   226 226 216 216
SURV 0 0   0 0 0 0
SXQOL 888 183 21% 667 -220 593 -295
Total 1188 607   2210 1024 2103 915

10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

ALL ACCRUAL REGISTRATIONS

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 1607 350 22% 1277 -329 1122 -485
CCD 0 57   208 208 141 141
ERLYTX 76 22 29% 80 4 88 12
GI 479 44 9% 160 -318 184 -295
GU 450 84 19% 306 -143 377 -73
GYN 57 0 0% 0 -57 0 -57
LEUK 219 200 91% 730 511 756 537
LUNG 567 176 31% 642 75 565 -2
LYMPH 225 110 49% 401 176 394 169
MELAN 55 0 0% 0 -55 180 125
MMYEL 239 30 13% 109 -129 113 -126
MULT 0 13   47 47 35 35
OTHER 0 21   76 76 86 86
PEOLC 0 10   36 36 118 118
PREV 0 62   226 226 216 216
SURV 0 0   0 0 0 0
SXQOL 888 183 21% 667 -220 595 -293
Total 4862 1362   4965 108 4970 108

10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

THERAPEUTIC REGISTRATIONS BY SWOG INSTITUTIONS ONLY (TXCA=Y)

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 1018 229 22% 835 -182 716 -302
ERLYTX 76 11 14% 40 -35 44 -32
GI 421 35 8% 127 -293 134 -287
GU 375 59 16% 215 -159 299 -76
GYN 57 0 0% 0 -57 0 -57
LEUK 122 22 18% 80 -41 85 -37
LUNG 441 42 10% 153 -287 127 -314
LYMPH 129 75 58% 273 144 260 131
MELAN 55 0 0% 0 -55 116 61
MMYEL 85 19 22% 69 -15 68 -17
MULT 0 7   25 25 15 15
OTHER 0 17   62 62 51 51
PREV 0 0   0 0 0 0
SXQOL 0 0   0 0 2 2
Total 2779 516   1879 -893 1917 -862

10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

NON-THERAPEUTIC STUDIES FOR SWOG INSTITUTIONS ONLY (TXCA=N)

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 16 0 0% 0 -16 0 -16
CCD 0 48   175 175 120 120
ERLYTX 0 3   10 10 11 11
GU 0 6   21 21 6 6
LEUK 69 73 106% 266 197 270 201
LUNG 30 60 200% 219 189 225 195
LYMPH 53 1 2% 3 -49 1 -52
MMYEL 92 0 0% 0 -92 0 -92
OTHER 0 4   14 14 35 35
PEOLC 0 8   29 29 85 85
PREV 0 61   222 222 215 215
SURV 0 0   0 0 0 0
SXQOL 750 143 19% 521 -228 418 -332
Total 1010 407   1480 472 1386 376

10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

ALL ACCRUAL REGISTRATIONS BY SWOG INSTITUTIONS ONLY

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 1034 229 22% 835 -198 716 -318
CCD 0 48   175 175 120 120
ERLYTX 76 14 18% 51 -24 55 -21
GI 421 35 8% 127 -293 134 -287
GU 375 65 17% 237 -137 305 -70
GYN 57 0 0% 0 -57 0 -57
LEUK 191 95 50% 346 155 355 164
LUNG 471 102 22% 372 -98 352 -119
LYMPH 182 76 42% 277 95 261 79
MELAN 55 0 0% 0 -55 116 61
MMYEL 177 19 11% 69 -107 68 -109
MULT 0 7   25 25 15 15
OTHER 0 21   76 76 86 86
PEOLC 0 8   29 29 85 85
PREV 0 61   222 222 215 215
SURV 0 0   0 0 0 0
SXQOL 750 143 19% 521 -228 420 -330
Total 3789 923   3362 -420 3303 -486

10-APR-2026 6:11

SWOG CURRENT AND PROJECTED ACCRUAL BY COMMITTEE

ALL ACCRUAL REGISTRATIONS TO CANCER CONTROL STUDIES

27% of Calendar Year is Past

COMMITTEE Base Accrual
2010		 2026
Accrual
to date		 Percentage
of Base
Accrual		 Projected
2026
Accrual		 Projected
Increase
<Decrease>
from Base		 Accrual
Last
12 Months		 12 Month
Increase
<Decrease>
from Base
BREAST 65 350 538% 1277 1212 1121 1056
CCD 0 57   208 208 141 141
ERLYTX 0 3   10 10 4 4
GI 81 21 26% 76 -4 83 2
GU 215 48 22% 175 -39 237 22
LEUK 0 9   32 32 41 41
LUNG 53 7 13% 25 -27 58 5
LYMPH 7 25 357% 91 84 75 68
MELAN 0 0   0 0 0 0
MMYEL 0 29   105 105 102 102
OTHER 0 7   25 25 41 41
PEOLC 0 10   36 36 118 118
PREV 0 62   226 226 216 216
SURV 0 0   0 0 0 0
SXQOL 880 183 21% 667 -212 595 -285
Total 1301 811   2953 1656 2832 1531

10-APR-2026 6:11

SWOG OPEN AND TEMPORARILY CLOSED STUDIES

Comm. Phase Study Stat
Center		 Open
Date		 Months
Open		 Total
Regs		 Accrual
Goal		 Monthly
Accrual
Rate		 Date of
Expected Closure or
Temporary Closure
BREAST II NRGBR005 Br, Stg II&IIIA, Post NAdj Chemo Br Conserv NRG 13APR2017:00:00:00   7     Dec-2022 Temp Close
  II-III NRGBR002 Brst, OMBC, II-III, SoC +/- SBRT and/or SA NRG 24DEC2014:00:00:00   1     May-2022 Temp Close
  III A011801 BRST, HER2+, T-DM1+Placebo v T-DM1+Tucatinib ALLIANCE 06JAN2021:00:00:00   55   0.0  
    A012103 Breast,StgT1cN1-2/T2-4N0-2,obsvsPembrolizumab ALLIANCE 03MAY2023:00:00:00   52   1.8  
    A012301 Breast, Early Stg, Tamoxifen ALLIANCE 05FEB2025:00:00:00   87   11.0  
    A012303 Breast, HER2+, Shortened Adj ALLIANCE 25JUL2025:00:00:00   1   0.2  
    MA39 BREAST, Node-Pos, Reg RT vs No Reg RT CCTG 30MAY2018:00:00:00   71   1.7  
    NRGBR009 Breast, EarlyStg, Adjuvant Chemo NRG 31AUG2023:00:00:00   40   3.2  
    S2206 Brst, Stg II-III, MP2, Neoadj Chemo +/- Durva SWOG 30OCT2023:00:00:00 29 353 960 18.7 Dec-2028
    S2212 Breast, TNBC, Neoadj Chemo + Pembro SWOG 21JUL2023:00:00:00 32 1310 2400 65.3 Aug-2027
CCD III S1703 Met Breast, STM-monitoring v Usual Care SWOG 16JUL2018:00:00:00 92 455 498 4.3 Jan-2027
    S2417CD Colrec Surv, Follow-up w/ CTAC site SWOG 04AUG2025:00:00:00 8 55 654 9.2 Sep-2031
  OTHER A231602C Blood Cancer, Assess Financial Difficulty ALLIANCE 15MAR2019:00:00:00   4     Feb-2021 Temp Close
    ACCL16N1 Guideline Consistent Treatment AYA ALL COG 18DEC2017:00:00:00   54     Aug-2022 Temp Close
    EAQ221CD Breast, Metastatic, Imp. Adherence ECOG-ACRIN 31OCT2023:00:00:00   5   0.2  
    EAQ222CD CostCOM, Cancer Patients, OOP Cost Com ECOG-ACRIN 29FEB2024:00:00:00   38   2.0  
ERLYTX II 21CTP.HN01 HN, Recur/Met, Amivantamab + Chemo SWOG 15SEP2025:00:00:00 6 2 50 0.3 Apr-2038
    A071401 Prog Meningiomas,SMO/AKT/NF2 Inhib ALLIANCE 28AUG2015:00:00:00   9   0.2  
    EAY191-S3 ComboMATCH: Adv Solid Tumors, Pac+Ipatasertib SWOG 06MAR2023:00:00:00   33 33   Dec-2025 Temp Close
    SN2426 cSCC, IC Met/Inop, Amivantamab v Cetuximab SWOG 28JAN2026:00:00:00 2 1 86    
  II-III S2012 Extrapulm NEC, Stg IV, Combo Chemo +/- Atezo SWOG 02DEC2021:00:00:00 52 149 189 4.8 Dec-2026
  III AGCT1531 Mult, Stg I-IV, Carbo vs Cisp, Ped &Adult COG 08MAY2017:00:00:00   5   0.2  
    EA7211 Sarc, Hi-Risk RetroPeritoneal, Neo+Sur ECOG-ACRIN 13JUN2023:00:00:00   2   0.3  
  OTHER EAY191 ComboMATCH ECOG-ACRIN 06MAR2023:00:00:00   21   0.2  
GI II CCTGNE1 Midgut NET, Unresect, 177 Lut vs Ever CCTG 05JUN2023:00:00:00   7   0.5  
    EA2192 Panc, APOLLO ECOG-ACRIN 29APR2021:00:00:00   6   0.0  
    S1922 Small Bowel,Ram+Pac vs FOLFIRI, mets/unresect SWOG 16DEC2019:00:00:00 75 46 54 0.3 Mar-2028
    S2104 Panc,Resect High-risk,Postop Adj Chemo vs Obs SWOG 14OCT2021:11:13:50 53 94 154 2.2 Jul-2028
  II-III EA2174 Esoph, Peri-Op Nivolumab +/- Ipilimumab ECOG-ACRIN 17JAN2019:00:00:00   6   0.0  
    EA2234 Gastric, all stg, Pac+Sys vs Sys ECOG-ACRIN 19AUG2025:00:00:00   1   0.2  
    NRGGI008 Colon, Stg III, Adj Chemo NRG 10MAR2022:00:00:00   60   2.8  
    S2303 Gas/Esoph/GEJ, Adv, Ram + Pac +/- Nivo SWOG 06MAY2024:00:00:00 23 90 224 5.3 May-2028
  III A022101 Colorectal, Metastatic, Ablative Tx ALLIANCE 10JAN2023:00:00:00   1   0.0  
    A022102 Gastric, FOLFIRINOX +/-Nivo vs FOLFOX +/ Nivo ALLIANCE 11JAN2023:00:00:00   38   0.8  
    CCTGCO32 Rectal, Early Stg, Neoadj/Exc/Obs vs ChemRad CCTG 29FEB2024:00:00:00   12   0.7  
    EA2222 Colorectal, Stg II-III, Hep Art Infusion ECOG-ACRIN 19OCT2023:00:00:00   7   0.2  
    NRGGI006 Esophagus, Stg I-IVA, PBT vs IMRT NRG 06MAR2019:00:00:00   1   0.0  
    S2433 PANC, KRAS WT, Met, SOC Chemo +/- Panitumumab SWOG 26DEC2025:00:00:00 3 0 94 0.0 > 15 Yrs
GU II A031702 GU, Mets, Cabozantinib+Nivo+Ipi (ICONIC) ALLIANCE 12APR2019:00:00:00   28   0.0  
    A032102 Prostate, All Stg, Precision Diagnostics ALLIANCE 11OCT2024:00:00:00   2   0.0  
    NRGGU012 Renal, Stg IV, Stereo Abl Rad Therapy NRG 30JUN2022:00:00:00   10   0.2  
    S2210 Pros, High Risk, BRCA, Neoadj Carbo SWOG 14AUG2023:00:00:00 31 6 44 0.2 > 15 Yrs
    S2427 Blad, MIBC, RT + Pembrolizumab SWOG 04SEP2025:00:00:00 7 9 111 1.5 Dec-2031
  II-III A032103 Urothelial, All Stg, MRD-Based Adj Tx ALLIANCE 09JAN2024:00:00:00   39   2.2  
    EA8192 Blad, High Grade UTUC, Durv + Chemo ECOG-ACRIN 06MAY2021:00:00:00   7   0.2  
  III A032201 Renal Cell, High-Risk, Pembro+Tiv ALLIANCE 05FEB2025:00:00:00   14   2.0  
    A032302 Prostate, Cast-Sens, Docetaxel ALLIANCE 25SEP2025:00:00:00   3   0.5  
    A032303 Bladder, High Grade, Gem+BCG vs BCG ALLIANCE 05JUN2025:00:00:00   3   0.5  
    CCTG-PR24 Prostate, Unfav, Stereo vs Brachy CCTG 11MAR2024:00:00:00   1   0.2  
    CCTG-PR26 Prostate, Cast Sensitive, Docetax CCTG 30JAN2025:00:00:00   1   0.0  
    EA8134 Penile, Local Adv, ILND +/- Chemo or ChemoRT ECOG-ACRIN 08SEP2017:00:00:00   25   0.7  
    EA8191 Pros, Local vs Systemic Thrpy ECOG-ACRIN 08OCT2020:00:00:00   66   0.0  
    NRGGU008 Pros,Node+, Abiraterone acetate + Apalutamide NRG 05MAR2020:00:00:00   16   0.0  
    NRGGU013 Prostate, High-Risk, Five Fraction Radiation NRG 13NOV2023:00:00:00   16   0.7  
    S1802 Pros, Stg IV, SST ± Surg/RT to Primary Tum SWOG 17SEP2018:00:00:00 90 1011 1273 8.7 Oct-2028
    S1931 RENAL, Stg IV, IO + Nephrectomy. vs IO Only SWOG 16NOV2020:00:00:00 64 149 336 2.2 Jun-2033
    S1937 Blad, Mets, Eribulin + Gem vs SOC SWOG 16FEB2021:00:00:00   132 184   Mar-2026 Temp Close
    S2312 Pros, MCRPC, Cab +/- Carb SWOG 03SEP2024:00:00:00 19 47 500 3.0 Oct-2038
LEUK II 21CTP.LEUK01 ALL, Ph+, Asciminib, Dasatinib and Prednisone SWOG 15MAY2025:00:00:00 10 0 55 0.0 > 15 Yrs
    A041703 ALL, Newly Dx, Inotuzumab Ozogamicin + Blinat ALLIANCE 16NOV2018:00:00:00   6   0.2  
    EA9213 T-ALL, dara-hyal for chemo refractory MRD ECOG-ACRIN 16JUN2022:00:00:00   4   0.2  
    MM1OA-EA02 MyeloMATCH: AML, New Dx, Ven+HMA ECOG-ACRIN 06JUN2024:00:00:00   17   1.3  
    MM1OA-S03 AML, Newly Dx, Ven+ASTX727 vs Ven+ASTX727+Ena SWOG 01APR2025:00:00:00 12 8 102 0.0 > 15 Yrs
    MM1YA-CTG01 MyeloMATCH: AML, New Dx w/ Int Risk, Ven+Chem CCTG 18JUL2024:00:00:00   8   0.5  
    MM1YA-S01 AML, High Risk, Age <60, 7+3 vs experimental SWOG 16MAY2024:00:00:00 22 67 335 4.0 Oct-2031
  III A041501 B-Cell ALL, Frontline Tx +/- Intuzumab Ozo ALLIANCE 01JUN2017:00:00:00   44   0.0  
    S1925 CLL/SLL, Newly Dx HR, Early vs Delayed V+O SWOG 14DEC2020:00:00:00 63 181 247 3.7 Sep-2027
  OTHER MYELOMATCH MSRP for the NCI myeloMATCH Clinical Trials SWOG 16MAY2024:00:00:00 22 1030   49.8  
LUNG II EA5162 NSCLC,StgIV/IIB,EGFR exon20 insertion,AZD9291 ECOG-ACRIN 05APR2018:00:00:00   4   0.0  
    S1900G EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu SWOG 03APR2023:00:00:00 36 25 66 0.5 Jan-2033
    S1900J MET Amplification: Amivantamab Hyaluronidase SWOG 27SEP2024:10:59:58 18 4 88 0.2 > 15 Yrs
    S1900K MET Exon 14: Tepotinib +/- Ramucirumab SWOG 18DEC2023:00:00:00 27 24 56 1.7 Nov-2027
    S2409 ESCLC, Durvalumab +/- Biomarker Directed Tx SWOG 08SEP2025:00:00:00 7 4 900 0.7 > 15 Yrs
  II-III A082002 Lung, Adv, Systemic Tx +/- SBRT ALLIANCE 21DEC2021:00:00:00   4   0.0  
    S1800E Non-Match: Docetaxel + Ramu +/- Cemiplimab SWOG 28APR2025:10:50:48 11 87 378 10.2 Aug-2028
  III A081801 ALCHEMIST4, ALK and EGFR negative, Chemo-IO ALLIANCE 03JUN2020:00:00:00   105   1.2  
    EA5182 NSCLC, Met EGFR mut, AZD9291+Beva vs AZD9291 ECOG-ACRIN 22OCT2020:00:00:00   26   0.2  
    EA5221 Lung, Advanced NSCLC, ChemoImmuno/Immuno ECOG-ACRIN 15FEB2024:00:00:00   4   0.2  
    NRGLU008 Lung NSCL, StgII-III, StereoBodyRad/MedChemo NRG 10MAY2023:00:00:00   5   0.0  
    S2402 NSCLC, All Stg, Periop Vs Adj Tx ALLIANCE 11DEC2024:00:00:00   8   0.7  
    S2414 NSCLC, Stg II-IIIB, Durva vs Surveillance SWOG 14MAR2025:00:00:00 12 8 306 0.8 > 15 Yrs
  OTHER LUNGMAP NSCLC, Adv, Master SWOG 28JAN2019:00:00:00 86 3970   32.7  
LYMPH II A051902 PTCL,CHO(E)PvCC-486-CHO(E)PvDuvelisib-CHO(E)P ALLIANCE 30JUL2021:00:00:00   19   0.0  
    EA4231 Lymph, DL B-Cell, Ven+Ib+Pred+Ob+Rev ECOG-ACRIN 24JUN2025:00:00:00   1   0.2  
    S2114 NHL, Rel/Ref, CD19 CAR-T +/- Consolidation SWOG 23FEB2023:11:55:36 37 204 396 6.8 Aug-2028
    S2207 LBCL, Transplant Inelig, Targeted Tx + Tafa SWOG 30JUN2023:11:49:39   39 241   Mar-2026 Temp Close
  II-III S1918 DLBCL, Adv, Age 75+, CC-486 +/- R-miniCHOP SWOG 19MAR2021:00:00:00   136 422   Apr-2025 Temp Close
  III A052101 Lymph, Stg I-IV, Cont v Intermittent Zanub ALLIANCE 08SEP2023:00:00:00   33   1.7  
    AHOD2131 cHL,StgI-II,StdTherapyvImmuno-oncologyTherapy COG 28APR2023:00:00:00   95   4.0  
    EA4232 Lymph, Peri T Cell, Auto Stem ECOG-ACRIN 30JAN2025:00:00:00   2   0.2  
    S2308 FL, LTB, Mosunetuzumab vs Rituximab SWOG 01AUG2024:00:00:00 20 294 600 17.3 Sep-2027
MELAN II A091903 Melan, Resected Mucosal, Adj Nivo +/- Cabo ALLIANCE 01JUN2022:00:00:00   1   0.0  
MMYEL II EAA173 MYEL, SMM, Rd +/- Daratumumab ECOG-ACRIN 30APR2019:00:00:00   42   0.5  
    S2005 WM, Prev. Untreated, I/R or Z v V/R SWOG 24JUN2021:00:00:00 57 23 92 0.7 Nov-2034
  III EAA181 Myel, Newly Dx, DRd=>DRd+/-Btz=>DR (EQUATE) ECOG-ACRIN 27OCT2020:00:00:00   47   0.3  
    S1803 MM, Maintenance, Len vs Len/Dara SWOG 27JUN2019:00:00:00 81 1338 1100 0.0 000-0000
    S2209 MM, Newly Dx, VRd-R->R v DRd-R->R v DRD-DR->D SWOG 30MAY2023:00:00:00 34 125 510 3.8 Aug-2034
    S2213 AL Amyloidosis, Newly Dx, Dara-VCD v ASCT SWOG 01DEC2023:00:00:00 28 41 142 2.8 Mar-2029
MMYL II A062102 MMYL, All Stg, Iberdomide Tx ALLIANCE 04APR2024:00:00:00   0   0.0  
MULT II S2101 Melan or HNSCC, Adv, Cabo + Nivo SWOG 14OCT2022:10:48:23 41 89 220 5.0 Jun-2028
OTHER II A092105 Nasopharyngeal, Adv, Niv/Ip +- Cab ALLIANCE 18SEP2023:00:00:00   1   0.0  
    EA3132 HN SCC, Stg III-IV , Adj RT +/- Cisp ECOG-ACRIN 29MAR2016:00:00:00   22   0.0  
    EA3191 HN, High Risk HNSCC, Adj +/- Pembro ECOG-ACRIN 08JAN2021:00:00:00   13   0.0  
    NRGGY032 Endo, ErlyStg Pole/p53, Adj Tx NRG 16APR2024:00:00:00   2   0.2  
    NRGHN010 HER2+ SGC, T-DM1 vs TH NRG 30SEP2022:00:00:00   4   0.0  
  II-III A072201 Glioblastoma, Recurrent, Block vs SOC ALLIANCE 03SEP2024:00:00:00   6   0.8  
    NRGGY026 Endomet, Stage I-IV, Pac/Car w/ HER HYL/PHE NRG 12AUG2022:00:00:00   3   0.0  
    NRGHN006 HN, Erly Stg, Biopsy vs Dissection NRG 08JUL2020:00:00:00   7   0.7  
    NRGHN009 HN, RT + HD Cisp vs RT + LD Cisp for SCCHN NRG 27OCT2021:00:00:00   19   0.0  
    R1216 HN, Adv,Cis vs Dtx vs Dtx+Cetux NRG 18MAR2013:00:00:00   8   0.2  
  III A092205 HN Squamous, Rec/Metas, Pem vs Pem+Cet ALLIANCE 21NOV2024:00:00:00   1   0.0  
    AGCT1532 Inter/Poor Met GCTs, Accel v Std BEP Chemo COG 30JUL2018:00:00:00   5     Temp Close
    CCTGHN11 HN, All Stg, Guided Elec Contra Neck Tx CCTG 29SEP2022:00:00:00   1   0.0  
    CE7 Brain, 5+ Metastases, Radiosurg/Radiotherapy CCTG 25MAY2018:00:00:00   1   0.0  
    EA7222 Sarcoma, Poorly Diff, Dox+Pembro vs Dox ECOG-ACRIN 13JUN2024:00:00:00   14   0.8  
    NRG-HN014 HN, Stg III/IV, Neoadj vs SOC NRG 20DEC2024:00:00:00   6   1.0  
    NRGBN003 Mening, Grd II, Observation vs Irradiation NRG 14JUN2017:00:00:00   3   0.0  
    NRGBN013 Brain, Intact Metas, SRS vs FSRS NRG 28AUG2024:00:00:00   7   0.3  
    NRGGY036 Ovary, All Stg, Olaparib +/- Bevac NRG 16JAN2025:00:00:00   4   0.3  
  OTHER A151804 irAEs, National Biorepository to Adv Studies ALLIANCE 31JAN2020:00:00:00   52   0.7  
PEOLC III S1501 Surv, Breast Stg IV, Card Tox w/ Carvedilol SWOG 15SEP2017:00:00:00 102 389 491 2.3 Nov-2029
    S2408 Panc Fistula Prevention, Lanreotide SWOG 14FEB2025:00:00:00   63 274   Mar-2026 Temp Close
PREV II EA2185 Panc, Impact of Panc Cyst Surveillance ECOG-ACRIN 16JAN2020:00:00:00   19   0.0  
  III NRGCC005 Colon,Non-AdvancedAdenomas,Colonoscopy5v10yrs NRG 06OCT2021:00:00:00   160   8.7  
  OTHER A212102 Blind Ref Set for Multicancer Early Detection ALLIANCE 01AUG2022:00:00:00   312   10.7  
    NRGCC008 Ovar, BRCA1, non-inferiority of BLS vs BSO NRG 23JUN2020:00:00:00   15   0.3  
SXQOL III A211901 Cancer survivors who smoke, txt cessation ALLIANCE 01DEC2021:00:00:00   17   0.3  
    ACCL1931 Leuk, All Stg, Levocarnitine Prophylaxis COG 14AUG2023:00:00:00   13   1.2  
    NRGCC010 Endo, Stg I, LN Map for LE Limb Dysfunction NRG 19SEP2022:00:00:00   15   0.0  
    NRGCC011 Breast, Survivors, Cog Training NRG 02FEB2024:00:00:00   45   1.3  
    NRGCC015 E-Mindfulness After Breast Cancer NRG 12JUN2025:00:00:00   3   0.5  
    S2205 ICE COMPRESS: Reduction of CIPN from Taxanes SWOG 16MAR2023:00:00:00 36 586 777 20.2 Jan-2027
  OTHER S2013 I-CHECKIT: ICI toxicity risk prediction study SWOG 16AUG2021:00:00:00 55 2462 3609 27.2 Oct-2029
 
Accrual goals assume studies are not terminated early as a result of interim analysis.
Studies may have accrual objectives specific to subsets of patients and are not reflected in this report.
Monthly accrual rate is projected from accrual in the previous six months for studies open at least three months.
Expected closure dates are calculated for SWOG coordinated studies that have been open at least three months.

10-APR-2026 6:11

OPEN AND TEMPORARILY CLOSED STUDIES: BY STUDY TYPE, COMMITTEE, INTERGROUP, SWOG/OTHER STAT CENTER

Phase Comm. Int
grp		 Stat
Center		 Study NCIPROTO CA
Cntrl
Study		 Temp
Close
OTHER CCD     EAQ221CD Breast, Metastatic, Imp. Adherence   Y  
        EAQ222CD CostCOM, Cancer Patients, OOP Cost Com   Y  
    Y COG ACCL16N1 Guideline Consistent Treatment AYA ALL ACCL16N1CD Y Y
    Y ALLIANCE A231602C Blood Cancer, Assess Financial Difficulty A231602CD Y Y
  ERLYTX Y ECOG-ACRIN EAY191 ComboMATCH EAY191 N  
  LEUK Y SWOG MYELOMATCH MSRP for the NCI myeloMATCH Clinical Trials MYELOMATCH N  
  LUNG Y SWOG LUNGMAP NSCLC, Adv, Master LUNGMAP N  
  OTHER Y ALLIANCE A151804 irAEs, National Biorepository to Adv Studies A151804 N  
  PREV Y ALLIANCE A212102 Blind Ref Set for Multicancer Early Detection A212102 Y  
    Y NRG NRGCC008 Ovar, BRCA1, non-inferiority of BLS vs BSO NRG-CC008 Y  
  SXQOL Y SWOG S2013 I-CHECKIT: ICI toxicity risk prediction study S2013 Y  
II BREAST Y NRG NRGBR005 Br, Stg II&IIIA, Post NAdj Chemo Br Conserv NRG-BR005 N Y
  ERLYTX N   21CTP.HN01 HN, Recur/Met, Amivantamab + Chemo   N  
    Y SWOG EAY191-S3 ComboMATCH: Adv Solid Tumors, Pac+Ipatasertib EAY191-S3 N Y
    Y SWOG SN2426 cSCC, IC Met/Inop, Amivantamab v Cetuximab SN2426 N  
    Y ALLIANCE A071401 Prog Meningiomas,SMO/AKT/NF2 Inhib A071401 N  
  GI     EA2192 Panc, APOLLO   N  
    Y SWOG S1922 Small Bowel,Ram+Pac vs FOLFIRI, mets/unresect S1922 N  
    Y SWOG S2104 Panc,Resect High-risk,Postop Adj Chemo vs Obs S2104 N  
    Y CCTG CCTGNE1 Midgut NET, Unresect, 177 Lut vs Ever CCTG-NE1 Y  
  GU     A032102 Prostate, All Stg, Precision Diagnostics   Y  
    Y SWOG S2427 Blad, MIBC, RT + Pembrolizumab S2427 N  
    Y SWOG S2210 Pros, High Risk, BRCA, Neoadj Carbo S2210 N  
    Y ALLIANCE A031702 GU, Mets, Cabozantinib+Nivo+Ipi (ICONIC) A031702 N  
    Y NRG NRGGU012 Renal, Stg IV, Stereo Abl Rad Therapy NRG-GU012 N  
  LEUK N   21CTP.LEUK01 ALL, Ph+, Asciminib, Dasatinib and Prednisone   N  
        EA9213 T-ALL, dara-hyal for chemo refractory MRD   N  
    Y SWOG MM1OA-S03 AML, Newly Dx, Ven+ASTX727 vs Ven+ASTX727+Ena MM1OA-S03 N  
    Y SWOG MM1YA-S01 AML, High Risk, Age <60, 7+3 vs experimental MM1YA-S01 N  
    Y ECOG-ACRIN MM1OA-EA02 MyeloMATCH: AML, New Dx, Ven+HMA MM1OA-EA02 N  
    Y ALLIANCE A041703 ALL, Newly Dx, Inotuzumab Ozogamicin + Blinat A041703 N  
    Y CCTG MM1YA-CTG01 MyeloMATCH: AML, New Dx w/ Int Risk, Ven+Chem MM1YA-CTG01 N  
  LUNG Y SWOG S1900G EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu S1900G N  
    Y SWOG S1900K MET Exon 14: Tepotinib +/- Ramucirumab S1900K N  
    Y SWOG S2409 ESCLC, Durvalumab +/- Biomarker Directed Tx S2409 N  
    Y SWOG S1900J MET Amplification: Amivantamab Hyaluronidase S1900J N  
    Y ECOG-ACRIN EA5162 NSCLC,StgIV/IIB,EGFR exon20 insertion,AZD9291 EA5162 N  
  LYMPH Y SWOG S2207 LBCL, Transplant Inelig, Targeted Tx + Tafa S2207 Y Y
    Y SWOG S2114 NHL, Rel/Ref, CD19 CAR-T +/- Consolidation S2114 N  
    Y ECOG-ACRIN EA4231 Lymph, DL B-Cell, Ven+Ib+Pred+Ob+Rev EA4231 N  
    Y ALLIANCE A051902 PTCL,CHO(E)PvCC-486-CHO(E)PvDuvelisib-CHO(E)P A051902 N  
  MELAN     A091903 Melan, Resected Mucosal, Adj Nivo +/- Cabo   N  
  MMYEL Y SWOG S2005 WM, Prev. Untreated, I/R or Z v V/R S2005 N  
    Y ECOG-ACRIN EAA173 MYEL, SMM, Rd +/- Daratumumab EAA173 Y  
  MMYL     A062102 MMYL, All Stg, Iberdomide Tx   N  
  MULT Y SWOG S2101 Melan or HNSCC, Adv, Cabo + Nivo S2101 N  
  OTHER Y ECOG-ACRIN EA3132 HN SCC, Stg III-IV , Adj RT +/- Cisp EA3132 N  
    Y NRG NRGHN010 HER2+ SGC, T-DM1 vs TH NRG-HN010 N  
    Y NRG NRGGY032 Endo, ErlyStg Pole/p53, Adj Tx NRG-GY032 N  
    Y ECOG-ACRIN EA3191 HN, High Risk HNSCC, Adj +/- Pembro EA3191 N  
    Y ALLIANCE A092105 Nasopharyngeal, Adv, Niv/Ip +- Cab A092105 N  
  PREV Y ECOG-ACRIN EA2185 Panc, Impact of Panc Cyst Surveillance EA2185 Y  
II-III BREAST Y NRG NRGBR002 Brst, OMBC, II-III, SoC +/- SBRT and/or SA NRG-BR002 N Y
  ERLYTX Y SWOG S2012 Extrapulm NEC, Stg IV, Combo Chemo +/- Atezo S2012 N  
  GI     EA2234 Gastric, all stg, Pac+Sys vs Sys   N  
    Y SWOG S2303 Gas/Esoph/GEJ, Adv, Ram + Pac +/- Nivo S2303 Y  
    Y ECOG-ACRIN EA2174 Esoph, Peri-Op Nivolumab +/- Ipilimumab EA2174 N  
    Y NRG NRGGI008 Colon, Stg III, Adj Chemo NRG-GI008 N  
  GU     A032103 Urothelial, All Stg, MRD-Based Adj Tx   Y  
    Y ECOG-ACRIN EA8192 Blad, High Grade UTUC, Durv + Chemo EA8192 N  
  LUNG Y SWOG S1800E Non-Match: Docetaxel + Ramu +/- Cemiplimab S1800E N  
    Y ALLIANCE A082002 Lung, Adv, Systemic Tx +/- SBRT A082002 Y  
  LYMPH Y SWOG S1918 DLBCL, Adv, Age 75+, CC-486 +/- R-miniCHOP S1918 Y Y
  OTHER Y NRG R1216 HN, Adv,Cis vs Dtx vs Dtx+Cetux RTOG-1216 Y  
    Y ALLIANCE A072201 Glioblastoma, Recurrent, Block vs SOC A072201 N  
    Y NRG NRGHN006 HN, Erly Stg, Biopsy vs Dissection NRG-HN006 Y  
    Y NRG NRGHN009 HN, RT + HD Cisp vs RT + LD Cisp for SCCHN NRG-HN009 Y  
    Y NRG NRGGY026 Endomet, Stage I-IV, Pac/Car w/ HER HYL/PHE NRG-GY026 Y  
III BREAST Y SWOG S2206 Brst, Stg II-III, MP2, Neoadj Chemo +/- Durva S2206 Y  
    Y SWOG S2212 Breast, TNBC, Neoadj Chemo + Pembro S2212 Y  
    Y CCTG MA39 BREAST, Node-Pos, Reg RT vs No Reg RT CCTG MA.39 Y  
    Y ALLIANCE A011801 BRST, HER2+, T-DM1+Placebo v T-DM1+Tucatinib A011801 Y  
    Y ALLIANCE A012103 Breast,StgT1cN1-2/T2-4N0-2,obsvsPembrolizumab A012103 Y  
    Y NRG NRGBR009 Breast, EarlyStg, Adjuvant Chemo NRG-BR009 Y  
    Y ALLIANCE A012301 Breast, Early Stg, Tamoxifen A012301 Y  
    Y ALLIANCE A012303 Breast, HER2+, Shortened Adj A012303 Y  
  CCD Y SWOG S1703 Met Breast, STM-monitoring v Usual Care S1703 Y  
    Y SWOG S2417CD Colrec Surv, Follow-up w/ CTAC site S2417CD Y  
  ERLYTX Y COG AGCT1531 Mult, Stg I-IV, Carbo vs Cisp, Ped &Adult AGCT1531 Y  
    Y ECOG-ACRIN EA7211 Sarc, Hi-Risk RetroPeritoneal, Neo+Sur EA7211 Y  
  GI     A022101 Colorectal, Metastatic, Ablative Tx   N  
    Y SWOG S2433 PANC, KRAS WT, Met, SOC Chemo +/- Panitumumab S2433 Y  
    Y NRG NRGGI006 Esophagus, Stg I-IVA, PBT vs IMRT NRG-GI006 Y  
    Y CCTG CCTGCO32 Rectal, Early Stg, Neoadj/Exc/Obs vs ChemRad CCTG-CO32 Y  
    Y ECOG-ACRIN EA2222 Colorectal, Stg II-III, Hep Art Infusion EA2222 N  
    Y ALLIANCE A022102 Gastric, FOLFIRINOX +/-Nivo vs FOLFOX +/ Nivo A022102 N  
  GU N   S2312 Pros, MCRPC, Cab +/- Carb   N  
    Y SWOG S1802 Pros, Stg IV, SST ± Surg/RT to Primary Tum S1802 Y  
    Y SWOG S1937 Blad, Mets, Eribulin + Gem vs SOC S1937 N Y
    Y SWOG S1931 RENAL, Stg IV, IO + Nephrectomy. vs IO Only S1931 N  
    Y ALLIANCE A032201 Renal Cell, High-Risk, Pembro+Tiv A032201 Y  
    Y ECOG-ACRIN EA8134 Penile, Local Adv, ILND +/- Chemo or ChemoRT EA8134 Y  
    Y NRG NRGGU013 Prostate, High-Risk, Five Fraction Radiation NRG-GU013 Y  
    Y CCTG CCTG-PR24 Prostate, Unfav, Stereo vs Brachy CCTG-PR24 Y  
    Y ECOG-ACRIN EA8191 Pros, Local vs Systemic Thrpy EA8191 Y  
    Y ALLIANCE A032303 Bladder, High Grade, Gem+BCG vs BCG A032303 N  
    Y ALLIANCE A032302 Prostate, Cast-Sens, Docetaxel A032302 Y  
    Y NRG NRGGU008 Pros,Node+, Abiraterone acetate + Apalutamide NRG-GU008 Y  
    Y CCTG CCTG-PR26 Prostate, Cast Sensitive, Docetax CCTG-PR26 N  
  LEUK Y SWOG S1925 CLL/SLL, Newly Dx HR, Early vs Delayed V+O S1925 Y  
    Y ALLIANCE A041501 B-Cell ALL, Frontline Tx +/- Intuzumab Ozo A041501 N  
  LUNG     EA5221 Lung, Advanced NSCLC, ChemoImmuno/Immuno   Y  
    Y SWOG S2414 NSCLC, Stg II-IIIB, Durva vs Surveillance S2414 Y  
    Y NRG NRGLU008 Lung NSCL, StgII-III, StereoBodyRad/MedChemo NRG-LU008 Y  
    Y ALLIANCE A081801 ALCHEMIST4, ALK and EGFR negative, Chemo-IO A081801 Y  
    Y ECOG-ACRIN EA5182 NSCLC, Met EGFR mut, AZD9291+Beva vs AZD9291 EA5182 N  
    Y ALLIANCE S2402 NSCLC, All Stg, Periop Vs Adj Tx CTIU2317-A082304-S2402 N  
  LYMPH Y SWOG S2308 FL, LTB, Mosunetuzumab vs Rituximab S2308 N  
    Y ALLIANCE A052101 Lymph, Stg I-IV, Cont v Intermittent Zanub A052101 Y  
    Y ECOG-ACRIN EA4232 Lymph, Peri T Cell, Auto Stem EA4232 N  
    Y COG AHOD2131 cHL,StgI-II,StdTherapyvImmuno-oncologyTherapy AHOD2131 Y  
  MMYEL Y SWOG S1803 MM, Maintenance, Len vs Len/Dara S1803 Y  
    Y SWOG S2209 MM, Newly Dx, VRd-R->R v DRd-R->R v DRD-DR->D S2209 Y  
    Y SWOG S2213 AL Amyloidosis, Newly Dx, Dara-VCD v ASCT S2213 Y  
    Y ECOG-ACRIN EAA181 Myel, Newly Dx, DRd=>DRd+/-Btz=>DR (EQUATE) EAA181 Y  
  OTHER     CE7 Brain, 5+ Metastases, Radiosurg/Radiotherapy   Y  
    Y NRG NRGGY036 Ovary, All Stg, Olaparib +/- Bevac NRG-GY036 N  
    Y NRG NRGBN003 Mening, Grd II, Observation vs Irradiation NRG-BN003 Y  
    Y COG AGCT1532 Inter/Poor Met GCTs, Accel v Std BEP Chemo AGCT1532 Y Y
    Y CCTG CCTGHN11 HN, All Stg, Guided Elec Contra Neck Tx CCTG-HN11 Y  
    Y ALLIANCE A092205 HN Squamous, Rec/Metas, Pem vs Pem+Cet A092205 Y  
    Y NRG NRG-HN014 HN, Stg III/IV, Neoadj vs SOC NRG-HN014 Y  
    Y NRG NRGBN013 Brain, Intact Metas, SRS vs FSRS NRG-BN013 N  
    Y ECOG-ACRIN EA7222 Sarcoma, Poorly Diff, Dox+Pembro vs Dox EA7222 N  
  PEOLC Y SWOG S1501 Surv, Breast Stg IV, Card Tox w/ Carvedilol S1501 Y  
    Y SWOG S2408 Panc Fistula Prevention, Lanreotide S2408 Y Y
  PREV Y NRG NRGCC005 Colon,Non-AdvancedAdenomas,Colonoscopy5v10yrs NRG-CC005 Y  
  SXQOL     NRGCC011 Breast, Survivors, Cog Training   Y  
        NRGCC015 E-Mindfulness After Breast Cancer   Y  
    Y SWOG S2205 ICE COMPRESS: Reduction of CIPN from Taxanes S2205 Y  
    Y ALLIANCE A211901 Cancer survivors who smoke, txt cessation A211901 Y  
    Y COG ACCL1931 Leuk, All Stg, Levocarnitine Prophylaxis ACCL1931 Y  
    Y NRG NRGCC010 Endo, Stg I, LN Map for LE Limb Dysfunction NRG-CC010 Y  

10-APR-2026 6:11

PHASE III SWOG COORDINATED OPEN STUDIES

SORTED BY STUDY ID

Protocol
Number		 Study Accrual
Goal		 Open
Stat/Date		 Months
Open		 Accrual
as of
01Jan02		 Current Accrual Proj.
Annual
Accr.
Rate		 EXPCLOSE Proj.
Study
Duration
(Years)
S1501 S1501 Surv, Breast Stg IV, Card Tox w/ Carvedilol (PEOLC) 491 Y-09/15/17 102 389 389 28 Nov-2029 12.2
S1703 S1703 Met Breast, STM-monitoring v Usual Care (CCD) 498 Y-07/16/18 92 455 455 52 Jan-2027 8.5
S1800E S1800E Non-Match: Docetaxel + Ramu +/- Cemiplimab (LUNG) 378 Y-04/28/25 11 87 87 122 Aug-2028 3.3
S1802 S1802 Pros, Stg IV, SST ± Surg/RT to Primary Tum (GU) 1273 Y-09/17/18 90 1011 1011 104 Oct-2028 10.1
S1803 S1803 MM, Maintenance, Len vs Len/Dara (MMYEL) 1100 Y-06/27/19 81 1338 1338 0 000-0000 > 15 Yrs
S1918 S1918 DLBCL, Adv, Age 75+, CC-486 +/- R-miniCHOP (LYMPH) 422 T-03/19/21 60 136 136 0 > 15 Yrs > 15 Yrs
S1925 S1925 CLL/SLL, Newly Dx HR, Early vs Delayed V+O (LEUK) 247 Y-12/14/20 63 181 181 44 Sep-2027 6.7
S1931 S1931 RENAL, Stg IV, IO + Nephrectomy. vs IO Only (GU) 336 Y-11/16/20 64 149 149 26 Jun-2033 12.6
S1937 S1937 Blad, Mets, Eribulin + Gem vs SOC (GU) 184 T-02/16/21 61 132 132 42 Jun-2027 6.3
S2012 S2012 Extrapulm NEC, Stg IV, Combo Chemo +/- Atezo (ERLYTX) 189 Y-12/02/21 52 149 149 58 Dec-2026 5.0
S2205 S2205 ICE COMPRESS: Reduction of CIPN from Taxanes (SXQOL) 777 Y-03/16/23 36 586 586 242 Jan-2027 3.8
S2206 S2206 Brst, Stg II-III, MP2, Neoadj Chemo +/- Durva (BREAST) 960 Y-10/30/23 29 353 353 224 Dec-2028 5.1
S2209 S2209 MM, Newly Dx, VRd-R->R v DRd-R->R v DRD-DR->D (MMYEL) 510 Y-05/30/23 34 125 125 46 Aug-2034 11.2
S2212 S2212 Breast, TNBC, Neoadj Chemo + Pembro (BREAST) 2400 Y-07/21/23 32 1310 1310 784 Aug-2027 4.1
S2213 S2213 AL Amyloidosis, Newly Dx, Dara-VCD v ASCT (MMYEL) 142 Y-12/01/23 28 41 41 34 Mar-2029 5.3
S2303 S2303 Gas/Esoph/GEJ, Adv, Ram + Pac +/- Nivo (GI) 224 Y-05/06/24 23 90 90 64 May-2028 4.0
S2308 S2308 FL, LTB, Mosunetuzumab vs Rituximab (LYMPH) 600 Y-08/01/24 20 294 294 208 Sep-2027 3.1
S2312 Pros, MCRPC, Cab +/- Carb (GU) 500 Y-09/03/24 19 47 47 36 Oct-2038 14.1
S2408 S2408 Panc Fistula Prevention, Lanreotide (PEOLC) 274 T-02/14/25 13 63 63 78 Dec-2028 3.8
S2414 S2414 NSCLC, Stg II-IIIB, Durva vs Surveillance (LUNG) 306 Y-03/14/25 12 8 8 10 > 15 Yrs > 15 Yrs
S2417CD S2417CD Colrec Surv, Follow-up w/ CTAC site (CCD) 654 Y-08/04/25 8 55 55 110 Sep-2031 6.1
S2433 S2433 PANC, KRAS WT, Met, SOC Chemo +/- Panitumumab (GI) 94 Y-12/26/25 3 0 0 0 > 15 Yrs > 15 Yrs
 
Accrual goals assume studies are not terminated early as a result of interim analysis.
Studies may have accrual objectives specific to subsets of patients and are not reflected in this report.
Monthly accrual rate is projected from accrual in the previous six months for studies open at least three months.
Expected closure dates are calculated for SWOG coordinated studies that have been open at least three months.