03 FEB 2012 05:50                     MMYEL ACCRUAL REPORT - OPEN and recently closed STUDIES                                     
                                                                                                                                  
                                         O                                               REGS. REGS. REGS. REGS. REGS.            
                                       R P                                                LAST  LAST  LAST  LAST  LAST  # of  # of
                                       E E                                   ACCR. TOTAL    12     6     3    30     7  ACT.  CURR
STUDY                                  G N ARM                                GOAL REGS. Month Month Month  DAYS  DAYS INSTs  IRBs
-------------------------------------- - - --------------------------------- ----- ----- ----- ----- ----- ----- ----- ----- -----
S0204-Thal/Dex/Pred Tandem PBSCT       1 N 1  Induction/PBSC Mobilization       99   147     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     147     0     0     0     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                             147                                          
                                       2 N 2  Autologous PBSCT                  99   108     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     108     0     0     0     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                             108                                          
                                       3 Y 3  Prednisone + Thalidomide          99    80     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      80     0     0     0     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              80                                          
                                                                                                                                  
S0777-MM, Len Dex +/- Bortezomib       1 Y 1  Lenalidomide/Dex                 484   261   109    44    23     9     4   232    88
                                           2  Bortezomib/Lenalidomide/Dex            264   110    48    26    13     5            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     525   219    92    49    22     9            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                             525                                          
                                                                                                                                  
CTN0702-Single v Tandem Autol transpla 1 E Total Registrations                        12    11     5     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      12    11     5     0     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              12                                          
                                                                                                                                  
E3A06-Lenalidomide vs Observation      1 E Total Registrations                         7     6     2     1     0     0   116    52
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       7     6     2     1     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                               7                                          
                                                                                                                                  






























                                                                 

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03 FEB 2012 05:50                            MMYEL Open Studies with No Registrations                                             
                                                                                                                                  
Study                                    Registration/Phase                  Open Date                                            
---------------------------------------- ----------------------------------- ---------                                            
S0777 MM, Len Dex +/- Bortezomib         2 Autologous Transplant             01-Apr-08                                            
S0833 Frontline MM, Total Therapy III    1 Induction                         15-Mar-11                                            
                                         2 Transplant                        15-Mar-11                                            
                                         3 Consolidation                     15-Mar-11                                            
                                         4 Maintenance                       15-Mar-11                                            
E4A08 MDex vs BMDex in untx pts w/AL     1 Endorsed Study                    22-Nov-10                                            













                                                                 

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