Table 1
| SWOG/ Support |
STUDY | R E G |
O P E N |
ARM | ACCR. GOAL |
TOTAL REGS. |
REGS. LAST 12 Month |
REGS. LAST 6 Month |
REGS. LAST 3 Month |
REGS. LAST 30 DAYS |
REGS. LAST 7 DAYS |
DATE OF FIRST REG. |
# of ACT. INSTs |
# of CURR IRBs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SWOG | S1320-Adv, BRAF mut, Inter v Contin | 1 | Y | 1 Lead-in Continuous Dosing | 280 | 213 | 66 | 37 | 19 | 3 | 1 | 09/19/2014 | 230 | 106 |
| 213 | 66 | 37 | 19 | 3 | 1 | |||||||||
| 2 | Y | 2 Continuous Dosing | 280 | 86 | 29 | 13 | 5 | 2 | 0 | 09/19/2014 | ||||
| 3 Intermittent Dosing | 84 | 23 | 13 | 6 | 5 | 1 | ||||||||
| 170 | 52 | 26 | 11 | 7 | 1 | |||||||||
| S1512-Melan, Adv, Desmoplastic, MK-3475 (pembro) | 1 | Y | 1 MK-3475 (pembrolizumab) | 77 | 7 | 6 | 4 | 2 | 0 | 0 | 02/06/2017 | 75 | 39 | |
| 7 | 6 | 4 | 2 | 0 | 0 | |||||||||
| S1616-MELAN, Adv, Ipilimumab ± Nivolumab | 1 | Y | 1 Ipilimumab | 94 | 2 | 2 | 2 | 1 | 0 | 0 | 10/23/2017 | 84 | ||
| 2 Nivolumab + Ipilimumab | 6 | 6 | 5 | 2 | 0 | 0 | ||||||||
| 8 | 8 | 7 | 3 | 0 | 0 | |||||||||
| Yes | EA6134-Adv, BRAF mut, D+T/Ipi+Niv vs Ipi+Niv/D+T | 1 | E | Total Registrations | 26 | 11 | 4 | 2 | 1 | 0 | 11/03/2015 | 346 | 146 | |
| 26 | 11 | 4 | 2 | 1 | 0 | |||||||||
| 2 | E | Total Registrations | 7 | 4 | 2 | 2 | 0 | 0 | 11/03/2015 | |||||
| 7 | 4 | 2 | 2 | 0 | 0 | |||||||||
| EA6141-Melan, Avd, Nivolumab+Ipi ± Sargmostim | 1 | E | Total Registrations | 36 | 14 | 0 | 0 | 0 | 0 | 03/25/2016 | 303 | 120 | ||
| 36 | 14 | 0 | 0 | 0 | 0 | |||||||||