18-AUG-2026 6:10

Lung-MAP ACCRUAL REPORT

  O
P
E
N		 ACCR
GOAL		 TOTAL
REGS.		 REGS.
LAST
12
Month		 REGS.
LAST
6
Month		 REGS.
LAST
3
Month		 REGS.
LAST
30
DAYS		 REGS.
LAST
7
DAYS		 DATE OF
FIRST
REG.		 # of
ACT.
INSTs		 # of
CURR
IRBs
LUNGMAP Screening Protocol Registrations
Total     4084 376 179 82 26 5 02/06/2019 474 184
Screened at PD     1547 243 130 56 18 5      
Pre-Screened prior to PD     2511 116 43 21 7 0      
Treatment-naive     26 17 6 5 1 0      
ctDNA Specimen Submission     315 0 0 0 0 0      
Re-analysis Requests     537 28 13 4 2 1      
 
Sub-Study Assignments
LUNGMAP Sub-Study Assignments     2249 300 158 73 23 6      
Screened at PD     1315 240 131 59 19 5      
Pre-Screened prior to PD     850 40 19 8 2 1      
Treatment-naive     26 17 6 5 2 0      
After PD on a Lung_MAP Sub-Study     58 3 2 1 0 0      
 
Sub-Study Assignments (open studies only)
S1800E     435 259 139 61 20 6      
S1900G     41 10 7 5 0 0      
S1900J     18 6 3 0 0 0      
S1900K     44 24 8 6 2 0      
S1900N     1 1 1 1 1 0      
 
Sub-Study Registrations
LUNGMAP Sub-Study Registrations     665 145 77 42 13 3      
Initial sub-study registrations     652 144 76 41 13 3      
Subsequent sub-study registrations     13 1 1 1 0 0      
 
Patients Registered to a Sub-Study (open studies only)
S1800E: Non-Match: Docetaxel + Ramu +/- Cemiplimab   378 129 118 66 35 12 2 05/22/2025 358 118
Docetaxel plus Ramucirumab Y   67 61 35 18 8 1      
Cemiplimab plus Docetaxel and Ramucirumab Y   62 57 31 17 4 1      
S1900G: EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu   44 28 7 4 2 0 0 05/05/2023 336 107
Capmatinib + Osimertinib + Ramucirumab Y   16 5 2 2 0 0      
Capmatinib + Osimertinib Y   12 2 2 0 0 0      
S1900J: MET Amplification: Amivantamab Hyaluronidase   88 4 2 1 0 0 0 11/19/2024 280 86
Amivantamab Hyaluronidase Y   4 2 1 0 0 0      
S1900K: MET Exon 14: Tepotinib +/- Ramucirumab   56 30 18 6 5 1 1 08/08/2024 273 90
Tepotinib + Ramucirumab Y   21 13 5 5 1 1      
Tepotinib Y   9 5 1 0 0 0      
 

18-AUG-2026 6:10

Lung-MAP Open Studies with No Registrations

Study Registration/Phase Open Date # of
ACT.
INSTs		 # of
CURR
IRBs
S1900N AGAs: SG alone, I alone, or SG + I 1 Randomization 03-Aug-26 85 18