08-SEP-2026 6:10

Lung-MAP ACCRUAL REPORT

  O
P
E
N		 ACCR
GOAL		 TOTAL
REGS.		 REGS.
LAST
12
Month		 REGS.
LAST
6
Month		 REGS.
LAST
3
Month		 REGS.
LAST
30
DAYS		 REGS.
LAST
7
DAYS		 DATE OF
FIRST
REG.		 # of
ACT.
INSTs		 # of
CURR
IRBs
LUNGMAP Screening Protocol Registrations
Total     4099 364 169 76 22 2 02/06/2019 476 184
Screened at PD     1557 241 123 56 19 1      
Pre-Screened prior to PD     2516 107 40 18 3 1      
Treatment-naive     26 16 6 2 0 0      
ctDNA Specimen Submission     315 0 0 0 0 0      
Re-analysis Requests     541 29 13 7 5 1      
 
Sub-Study Assignments
LUNGMAP Sub-Study Assignments     2263 296 153 66 20 4      
Screened at PD     1327 239 127 56 19 4      
Pre-Screened prior to PD     852 38 18 7 1 0      
Treatment-naive     26 16 6 2 0 0      
After PD on a Lung_MAP Sub-Study     58 3 2 1 0 0      
 
Sub-Study Assignments (open studies only)
S1800E     447 257 134 57 18 4      
S1900G     41 9 7 4 0 0      
S1900J     18 5 1 0 0 0      
S1900K     44 22 8 2 0 0      
S1900N     3 3 3 3 2 0      
 
Sub-Study Registrations
LUNGMAP Sub-Study Registrations     670 139 76 37 9 3      
Initial sub-study registrations     657 138 75 36 9 3      
Subsequent sub-study registrations     13 1 1 1 0 0      
 
Patients Registered to a Sub-Study (open studies only)
S1800E: Non-Match: Docetaxel + Ramu +/- Cemiplimab   378 134 113 66 32 8 3 05/22/2025 360 118
Docetaxel plus Ramucirumab Y   68 56 32 15 3 1      
Cemiplimab plus Docetaxel and Ramucirumab Y   66 57 34 17 5 2      
S1900G: EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu   44 28 7 4 2 0 0 05/05/2023 338 107
Capmatinib + Osimertinib + Ramucirumab Y   16 5 2 2 0 0      
Capmatinib + Osimertinib Y   12 2 2 0 0 0      
S1900J: MET Amplification: Amivantamab Hyaluronidase   88 4 2 0 0 0 0 11/19/2024 281 86
Amivantamab Hyaluronidase Y   4 2 0 0 0 0      
S1900K: MET Exon 14: Tepotinib +/- Ramucirumab   56 30 17 6 3 1 0 08/08/2024 296 91
Tepotinib + Ramucirumab Y   21 13 5 3 1 0      
Tepotinib Y   9 4 1 0 0 0      
 

08-SEP-2026 6:10

Lung-MAP Open Studies with No Registrations

Study Registration/Phase Open Date # of
ACT.
INSTs		 # of
CURR
IRBs
S1900N AGAs: SG alone, I alone, or SG + I 1 Randomization 03-Aug-26 113 32