24-APR-2024 6:10

Lung-MAP ACCRUAL REPORT

  O
P
E
N		 ACCR
GOAL		 TOTAL
REGS.		 REGS.
LAST
12
Month		 REGS.
LAST
6
Month		 REGS.
LAST
3
Month		 REGS.
LAST
30
DAYS		 REGS.
LAST
7
DAYS		 DATE OF
FIRST
REG.		 # of
ACT.
INSTs		 # of
CURR
IRBs
LUNGMAP Screening Protocol Registrations
Total     3349 323 144 77 21 2 02/06/2019 405 176
Screened at PD     1198 77 32 15 1 0      
Pre-Screened prior to PD     2151 246 112 62 20 2      
ctDNA Specimen Submission     315 0 0 0 0 0      
Re-analysis Requests     437 112 51 26 9 1      
 
Sub-Study Assignments
LUNGMAP Sub-Study Assignments     1716 62 24 13 2 0      
Screened at PD     972 34 14 8 1 0      
Pre-Screened prior to PD     692 28 10 5 1 0      
After PD on a Lung_MAP Sub-Study     52 0 0 0 0 0      
 
Sub-Study Assignments (open studies only)
S1900E     232 42 17 7 2 0      
S1900G     17 17 5 4 0 0      
S1900K     2 2 2 2 0 0      
 
Sub-Study Registrations
LUNGMAP Sub-Study Registrations     479 34 14 6 1 0      
Initial sub-study registrations     467 34 14 6 1 0      
Subsequent sub-study registrations     12 0 0 0 0 0      
 
Patients Registered to a Sub-Study (open studies only)
S1900E: KRAS G12C: Sotorasib (AMG 510)   116 112 23 10 3 1 0 04/16/2021 304 125
Cohort 1: TP53 N   48 10 3 0 0 0      
Cohort 2: STK11 Y   26 8 4 2 1 0      
Cohort 3: All Others Y   38 5 3 1 0 0      
S1900G: EGFR-Mut, MET-Amp: Capmat + Osimert +/- Ramu   66 11 11 4 3 0 0 05/05/2023 253 104
Capmatinib + Osimertinib + Ramucirumab Y   4 4 1 1 0 0      
Capmatinib + Osimertinib Y   7 7 3 2 0 0      
 

24-APR-2024 6:10

Lung-MAP Open Studies with No Registrations

Study Registration/Phase Open Date # of
ACT.
INSTs		 # of
CURR
IRBs
S1900K MET Exon 14: Tepotinib +/- Ramucirumab 1 Randomization 18-Dec-23 184 68