03 FEB 2012 05:50                      GI ACCRUAL REPORT - OPEN and recently closed STUDIES                                       
                                                                                                                                  
                                         O                                               REGS. REGS. REGS. REGS. REGS.            
                                       R P                                                LAST  LAST  LAST  LAST  LAST  # of  # of
                                       E E                                   ACCR. TOTAL    12     6     3    30     7  ACT.  CURR
STUDY                                  G N ARM                                GOAL REGS. Month Month Month  DAYS  DAYS INSTs  IRBs
-------------------------------------- - - --------------------------------- ----- ----- ----- ----- ----- ----- ----- ----- -----
S1005-Gastric/GEJ, Adv, MK-2206        1 Y 1  MK-2206                           64    25    25    15    12     3     2   149    57
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      25    25    15    12     3     2            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              25                                          
                                                                                                                                  
S0518-CARCINOID,ADV,OCTREO/ALPHA/BEV   1 Y 1  Octreotide, Bevacizumab          424   187    40    20     9     3     0   221    88
                                           2  Octreotide,Interferon Alpha-2b         188    41    20    10     3     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     375    81    40    19     6     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                             375                                          
                                                                                                                                  
S0518-Carcinoid,Adv,Octreo/Alpha/Bev   2 Y 3  Octreotide, Bevacizumab          424    63     7     3     0     0     0   221    88
                                           4  Octreotide,Interferon Alpha-2b          35     6     2     2     1     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      98    13     5     2     1     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              98                                          
                                                                                                                                  
S0713-Rect,Stg2-3,Ox/Cape/Cet+RT->SRG  1 Y 1  Oxal/Cape/Cetux + RT->Surgery     88    55    27    12     4     1     1   155    44
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      55    27    12     4     1     1            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              55                                          
                                                                                                                                  
S0809-EHCC,Adj,Cape+Gem==>Cape+RT      1 Y 1  Cape+Gem=>Cape+RT                 88    99    50    23     9     0     0   183    75
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      99    50    23     9     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              99                                          
                                                                                                                                  
C80405-GI,Met,FOLFOX/FIRI,Bev,Cetux    1 E Total Registrations                2289   640    82    33    19     5     2   353   180
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     640    82    33    19     5     2            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                             640                                          
                                                                                                                                  
C80702-Adj FOLFOX+Celecoxib or Placebo 1 E Total Registrations                       113    84    43    20    11     1   399   181
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     113    84    43    20    11     1            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                             113                                          
                                                                                                                                  
C80802-Soraf+Doxorubicin vs Sorafenib  1 E Total Registrations                         3     3     2     1     0     0          46
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       3     3     2     1     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                               3                                          
                                                                                                                                  
E1208-Chemo Soraf. in Unresect HCC     1 E Total Registrations                        16    14    10     6     4     1   140    73
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      16    14    10     6     4     1            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                              16                                          
                                                                                                                                  
R0848-Panc, Adj, Erlotinib v ChemoRT   1 E Total Registrations                         6     4     3     2     1     0          90
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       6     4     3     2     1     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                               6                                          
                                                                                                                                  
R1010-Trastuz + Tri Tx of HER2-Overex  1 E Total Registrations                         1     1     1     1     0     0          47
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       1     1     1     1     0     0            
                                                                                                                                  
                                       * *                                   ***** -----                               ***** *****
                                       s                                               1                                          
                                                                                                                                  












                                                                 

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