03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                                      Therapeutic Registrations Only (Txca=Y)                                    
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST            4059        188         5%      2018     <2041>      1446     <2613>                           
ERLYTX              41          0         0%         0       <41>         4       <37>                           
GI                 471         32         7%       344      <127>       383       <88>                           
GU                 810         69         9%       741       <69>       439      <371>                           
GYN                  0          0                    0         0         57        57                            
LEUK               323         25         8%       268       <55>       178      <145>                           
LUNG               246         42        17%       451       205        554       308                            
LYMPH              102         26        25%       279       177        189        87                            
MELAN              111         13        12%       140        29         73       <38>                           
MMYEL              123         24        20%       258       135        236       113                            
          ------------ ----------            --------- ---------- --------- ----------                           
                  6286        419                 4498     <1788>      3559     <2727>                           
                                                                                                                 
                                                                                                                 







                                                         
03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                                        Non-Therapeutic Registrations Only                                       
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST              64          0         0%         0       <64>        14       <50>                           
GI                   0          0                    0         0          4         4                            
GU                   0          2                   21        21          9         9                            
LEUK               328          0         0%         0      <328>        53      <275>                           
LUNG                94          0         0%         0       <94>         8       <86>                           
LYMPH               42          0         0%         0       <42>         4       <38>                           
MMYEL               75          0         0%         0       <75>        16       <59>                           
PREV                 0          1                   11        11          4         4                            
SXQOL               33          0         0%         0       <33>         0       <33>                           
          ------------ ----------            --------- ---------- --------- ----------                           
                   636          3                   32      <604>       112      <524>                           
                                                                                                                 
                                                                                                                 









                                                         
03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                                             All Initial Registrations                                           
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST            4123        188         5%      2018     <2105>      1460     <2663>                           
ERLYTX              41          0         0%         0       <41>         4       <37>                           
GI                 471         32         7%       344      <127>       387       <84>                           
GU                 810         71         9%       762       <48>       448      <362>                           
GYN                  0          0                    0         0         57        57                            
LEUK               651         25         4%       268      <383>       231      <420>                           
LUNG               340         42        12%       451       111        562       222                            
LYMPH              144         26        18%       279       135        193        49                            
MELAN              111         13        12%       140        29         73       <38>                           
MMYEL              198         24        12%       258        60        252        54                            
PREV                 0          1                   11        11          4         4                            
SXQOL               33          0         0%         0       <33>         0       <33>                           
          ------------ ----------            --------- ---------- --------- ----------                           
                  6922        422                 4530     <2392>      3671     <3251>                           
                                                                                                                 
                                                                                                                 






                                                         

                                                                                                            
03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                           Therapeutic Registrations by SWOG Institutions Only (Txca=Y)                          
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST            2292        116         5%      1245     <1047>       959     <1333>                           
ERLYTX              41          0         0%         0       <41>         4       <37>                           
GI                 421         27         6%       290      <131>       321      <100>                           
GU                 599         60        10%       644        45        396      <203>                           
GYN                  0          0                    0         0         57        57                            
LEUK               192         23        12%       247        55        155       <37>                           
LUNG               231         33        14%       354       123        435       204                            
LYMPH               95         17        18%       183        88        111        16                            
MELAN               97         13        13%       140        43         73       <24>                           
MMYEL               64         16        25%       172       108        144        80                            
          ------------ ----------            --------- ---------- --------- ----------                           
                  4032        305                 3274      <758>      2655     <1377>                           
                                                                                                                 
                                                                                                                 







                                                         
03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                              Non-Therapeutic Registrations by SWOG Institutions Only                            
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST              10          0         0%         0       <10>         1        <9>                           
GI                   0          0                    0         0          4         4                            
GU                   0          2                   21        21          9         9                            
LEUK               318          0         0%         0      <318>        53      <265>                           
LUNG                78          0         0%         0       <78>         7       <71>                           
LYMPH               42          0         0%         0       <42>         4       <38>                           
MMYEL               75          0         0%         0       <75>        16       <59>                           
PREV                 0          1                   11        11          4         4                            
SXQOL               33          0         0%         0       <33>         0       <33>                           
          ------------ ----------            --------- ---------- --------- ----------                           
                   556          3                   32      <524>        98      <458>                           
                                                                                                                 
                                                                                                                 









                                                         
03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                                  All Initial Registrations by SWOG Institutions                                 
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST            2302        116         5%      1245     <1057>       960     <1342>                           
ERLYTX              41          0         0%         0       <41>         4       <37>                           
GI                 421         27         6%       290      <131>       325       <96>                           
GU                 599         62        10%       666        67        405      <194>                           
GYN                  0          0                    0         0         57        57                            
LEUK               510         23         5%       247      <263>       208      <302>                           
LUNG               309         33        11%       354        45        442       133                            
LYMPH              137         17        12%       183        46        115       <22>                           
MELAN               97         13        13%       140        43         73       <24>                           
MMYEL              139         16        12%       172        33        160        21                            
PREV                 0          1                   11        11          4         4                            
SXQOL               33          0         0%         0       <33>         0       <33>                           
          ------------ ----------            --------- ---------- --------- ----------                           
                  4588        308                 3306     <1282>      2753     <1835>                           
                                                                                                                 
                                                                                                                 






                                                         
03 Feb 2012            Southwest Oncology Group Current and Projected Accrual by Committee                       
                                              Data as of 03 Feb 2012                                             
                                 Initial Registrations to Cancer Control Studies                                 
                                             9% of Calendar Year is Past                                         
                                                                                                                 
                                                        Projected             12 Month                           
                             2012 Percentage Projected   Increase   Accrual   Increase                           
          Base Accrual    Accrual    of Base      2012 (Decrease)      Last (Decrease)                           
Committee         2009    to date    Accrual   Accrual  from Base 12 Months  from Base                           
--------- ------------ ---------- ---------- --------- ---------- --------- ----------                           
BREAST             188         95        51%      1020       832        516       328                            
GI                   0          1                   11        11          4         4                            
GU                 496          0         0%         0      <496>         0      <496>                           
LUNG                88          0         0%         0       <88>        14       <74>                           
LYMPH                4          0         0%         0        <4>         0        <4>                           
PREV                 0          1                   11        11          4         4                            
SXQOL               33          0         0%         0       <33>         0       <33>                           
          ------------ ----------            --------- ---------- --------- ----------                           
                   809         97                 1041       232        538      <271>                           
                                                                                                                 
                                                                                                                 











                                                         
03 FEB 2012                       Southwest Oncology Group    Open and Temporarily Closed Studies                                   
                                                                                                                                    
Accrual goals assume studies are not terminated early as a result of interim analysis.                                              
Studies may have accrual objectives specific to subsets of patients and are not reflected in this report.                           
Monthly accrual rate is projected from accrual in the previous six months for studies open at least three months.                   
Expected closure dates are calculated for SWOG coordinated studies that have been open at least three months.                       
                                                                                                                                    
                                                                                                                                    
                                                                                               Monthly Date of                      
                                                     Stat     Open       Months  Total Accrual Accrual Expected Closure or          
Comm.  Phase  Study                                  Center   Date         Open   Regs    Goal    Rate Temporary Closure            
------ ------ -------------------------------------- -------- ---------- ------ ------ ------- ------- --------------------         
BREAST II     Z1071 Node+, chemo + LN dissect        ACOSOG   22-JUL-09             67              .0                              
              S0800 Brst,Neoadj nabPAC+/-Bev->AC+G   SWOG     01-APR-10      22    123     200     9.0 Oct-2012                     
              C40603 Carb/Bev+Neoadj Pac, then AC/EC CALGB    21-MAY-10             35             1.5                              
              E3108 CYP2D6 Activity&SingleAgTamox    ECOG     08-OCT-10              5              .8                              
                                                                                                                                    
       III    C40101 Breast, Adj, Node neg, AC vs T  CALGB    15-MAY-02            733              .0                              
              JMA20 Breast, Early, Regional RT       NCIC     03-OCT-02              8              .0                              
              IBC24-02 Ovar Ftn suppress/premeno     IBCSG    04-AUG-03            187              .0                              
              B39 Stg 0-2, whole vs partial RT       NSABP    22-MAR-05             14              .0                              
              C70301 QOLEmployInformCareCost Analysi CALGB    24-OCT-05             35              .0                              
              s                                                                                                                     
                                                                                                                                    
              N0434 JMA27 Companion Study            NCCTG    08-DEC-05            100              .0                              
              JMA27B 5yr Adj Anast vs Exemestrane    NCIC     24-APR-06             94              .0                              
              PACCT-1 Assess of Ca Clinical Tests    ECOG     24-APR-06           1712              .0                              
              C40302 Endocrine +/1 Inhibition        CALGB    22-SEP-06             28              .0                              
              S0500 Brst,Adv,CTC,mntain v chnge tx   SWOG     01-OCT-06      64    604     500    10.7 May-2011                     
              E1105 Adv, Trastuzumab +/- Bev         ECOG     21-NOV-07             15              .0                              
              N063D ALTTO                            NCCTG    15-FEB-08            119              .0                              
              C40503 EndocrineTxCombo w/AntiVEGF Tx  CALGB    22-MAY-08             39              .7                              
              N0733 Her2+, Cap + Lap +/- IMC-A12     NCCTG    30-JUL-08              5              .3                              
              C40601 NeoAdj, Her-2+, Pac+Trast or La CALGB    08-DEC-08             30             2.3                              
              p                                                                                                                     
                                                                                                                                    
              MA32 Metformn vs Placebo               NCIC     08-JUL-10            250            37.2                              
              B47 Chemo vs Chemo + Trastuzumab       NSABP    07-JAN-11             15             1.5                              
              S1007 Breast,Adj,N1,Endocrine+/-Chemo  SWOG     15-JAN-11      12    252    4000    35.5 Nov-2020                     
              E2108 Early Local Tx for Int Prim Tum  ECOG     28-FEB-11              3              .3                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
ERLYTX I      S0711 Liver dysfunction PK,Dasatinib   SWOG     15-OCT-08             54      48         Jan-2012 Temp Close          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
GI     II     S0809 EHCC,Adj,Cape+Gem==>Cape+RT      SWOG     01-DEC-08      38     99      88     3.8 Dec-2011                     
              S0713 Rect,Stg2-3,Ox/Cape/Cet+RT->SRG  SWOG     01-FEB-09      36     55      88     2.0 Jun-2013                     
              S1005 Gastric/GEJ, Adv, MK-2206        SWOG     01-JAN-11      13     25      64     2.7 Apr-2013                     
                                                                                                                                    
       III    C80405 GI,Met,FOLFOX/FIRI,Bev,Cetux    CALGB    26-SEP-05            640    2289     5.7                              
              S0518 CARCINOID,ADV,OCTREO/ALPHA/BEV   SWOG     01-DEC-07      50    375     424     7.0 Aug-2012                     
              E1208 Chemo Soraf. in Unresect HCC     ECOG     09-NOV-09             16             1.8                              
              R0848 Panc, Adj, Erlotinib v ChemoRT   RTOG     08-DEC-09              6              .5                              
              C80802 Soraf+Doxorubicin vs Sorafenib  CALGB    22-FEB-10              3              .3                              
              C80702 Adj FOLFOX+Celecoxib or Placebo CALGB    22-JUN-10            113             7.7                              
              R1010 Trastuz + Tri Tx of HER2-Overex  RTOG     07-JAN-11              1              .2                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
GU     II     S0925 Andro Dep w/IMC vs. Andro Dep    SWOG     15-DEC-10      13     89     198     9.7 Jan-2013                     
              S1014 Pros, Mets, Abi Acetate          SWOG     09-AUG-11       5      0      38      .0 > 15 Yrs                     
                                                                                                                                    
       III    MDA3410 Consolidation chemo            MDACC    08-MAY-02             22              .0                              
              C90202 Pros,Bone mets,Zoledronic acid  CALGB    15-JAN-04             77              .5                              
              R0521 AS+RT vs AS+RT+Chemo             RTOG     22-DEC-05             18              .0                              
              R0415 Hypofrac v Conv 3D-CRG/IMRT      RTOG     24-APR-06              1              .0                              
              E2805 Renal, Adj Sunitib v Sorafinib   ECOG     08-MAY-06            583              .0                              
              E3805 CHAARTED                         ECOG     08-AUG-06            125             3.0                              
              R0524 Pac + Trastuzumab vs Pac alone   RTOG     08-DEC-06              5              .0                              
              C90203 Pros, Surgery +/- Neoadj Chemo  CALGB    22-DEC-06             83             1.2                              
              S0337 Blad, Instill Gem vs Saline      SWOG     15-JUL-07      54    312     408    14.2 Aug-2012                     
              PR11 Pros, Local, Watch vs Active Tx   NCIC     15-JUL-07              8              .0                              
              E2804 BeST Trial                       ECOG     21-MAR-08             44              .0                              
              C90601 Trans cell, blind bev vs placeb CALGB    07-AUG-09             39             2.0                              
              o                                                                                                                     
                                                                                                                                    
              C70807 MEAL Study                      CALGB    21-JAN-11              9             1.5                              
              S0931 EVEREST                          SWOG     01-APR-11      10    104    1218    16.2 Oct-2017                     
              S1011 Blad, Standard vs Extended LND   SWOG     01-AUG-11       6     11     620     1.8 > 15 Yrs                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
LEUK   II     S0535 APL,High Risk, ATRA/arsenic/GO   SWOG     15-NOV-07      50     54      77     2.0 Jan-2013                     
              C10403 ALL <40 yrs-Ped,Chemo. Regimen  CALGB    15-JAN-08      48     65     300     2.2                              
              S0703 AML, age 60+, Azacitidine G.O.   SWOG     01-DEC-08      38    132     153     4.3 Jun-2012                     
              C10404 CLL, Flu/Rituxan combinations   CALGB    15-MAR-09      34     26     300     1.0                              
              S0919 Rel AML: Pravastatin+Ida+Ara-C   SWOG     15-AUG-09      29     25      55     1.3 Dec-2013                     
              S0805 Ph+ ALL, Dasatinib/CVAD +/- BMT  SWOG     01-SEP-09      29     23      94     2.0 Jan-2015                     
              S0910 Rel ph-,B-ALL,Epratuzumab+Cy+Clo SWOG     15-AUG-10      17     25      35     2.2 Jun-2012                     
              E1908 Tx of PCL Leuk w/Alemtuz, Ritux  ECOG     22-OCT-10              1              .2                              
                                                                                                                                    
       III    E2905 MDS, Len vs Len + Epo            ECOG     09-FEB-09             21              .7                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
LUNG   I-II   S0905 Mesothem,cediranib+chemo,PhI/II  SWOG     15-MAR-10      22     25     128      .8 May-2022                     
                                                                                                                                    
       II     S0720 NSCLC,STG I,ERCC1/RRM1 TO ADJ TX SWOG     15-NOV-08             85      60         Apr-2011 Temp Close          
              S0709 NSCLC, Adv, PRO+, OSI-774+-Chemo SWOG     01-DEC-08      38     37     110     1.5 Feb-2016                     
              S0802 ESCLC,Topotecan+/-AVE0005,PhII   SWOG     15-MAY-09      32    188     190     4.5 Feb-2012                     
                                                                                                                                    
       III    E1505 Stg IB-IIIA chemo +/- Bev        ECOG     22-JUN-07            216             4.0                              
              C140503 NSCL, Lobect v Sublobar resect CALGB    09-JUL-07             13              .2                              
              C30610 SCLC, Thoracic RT               CALGB    21-MAR-08             29              .7                              
              S0819 NSCLC, ADV, CHEMO/BEV +/-CET     SWOG     15-JUL-09      30    643    1700    26.7 May-2015                     
              C30801 Selective COX-2 Inhibition      CALGB    22-JUL-10              5              .2                              
              N107C SRS vs WBRT on Resected Met Dz   NCCTG    08-JUL-11              0              .0                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
LYMPH  I-II   S0806 NHL, Adv, R-CHOP + SAHA          SWOG     15-NOV-10      14     25     105     2.8 Jun-2014                     
                                                                                                                                    
       II     S0816 HD, Adv, PET-Adapted Therapy     SWOG     01-JUL-09      31    235     200    11.8 Dec-2011                     
              C50604 Resp-Adapt Chemo Pos Emiss Tomo CALGB    22-JUL-10             15             1.3                              
              S1001 DLBCL, I-II, PET-Adapted Therapy SWOG     15-JUL-11       6      3     155      .5 > 15 Yrs                     
              S1106 NHL, Adv, R-HCVAD/R-Benda+PBSCT  SWOG     01-OCT-11       4      3     180      .7 > 15 Yrs                     
              S1108 NHL, Relapsed PTCL, MLN8237      SWOG     28-OCT-11       3      2      39      .6 Jan-2017                     
                                                                                                                                    
       III    C50303 R-CHOP v EPOCH-R                CALGB    15-SEP-06             43              .7                              
              CTN0701 Relapsed follic, allo transpla BMT-CTN  23-FEB-09              3              .0                              
              nt                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
MELAN  II     E2607 Dasatinib in KIT+ pts w/Melanoma ECOG     22-NOV-11              0                                              
                                                                                                                                    
       III    E1609 Adj Ipil AntiCTLA4 vs Interferon ECOG     08-JUN-11             41             6.8                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
MMYEL  II     S0833 Frontline MM, Total Therapy III  SWOG     15-MAR-11      10      0     100      .0 > 15 Yrs                     
                                                                                                                                    
       III    S0777 MM, Len Dex +/- Bortezomib       SWOG     01-APR-08      46    525     484    15.7 Dec-2011                     
              CTN0702 Single v Tandem Autol transpla BMT-CTN  09-JUN-10             12              .8                              
              nt                                                                                                                    
                                                                                                                                    
              E3A06 Lenalidomide vs Observation      ECOG     08-NOV-10              7              .3                              
              E4A08 MDex vs BMDex in untx pts w/AL   ECOG     22-NOV-10              0              .0                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
PREV   II     S0812 Breast, Prev, Vit D vs Placebo   SWOG     01-NOV-11       3      4     220     1.3 Dec-2025                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
SXQOL  III    S0927 Omega-3-Fatty Acid AI Joint Pain SWOG     01-FEB-12       0      0     246                                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    













































                                                                  
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