03 FEB 2012 05:50                    BREAST ACCRUAL REPORT - OPEN and recently closed STUDIES                                     
                                                                                                                                  
                                         O                                               REGS. REGS. REGS. REGS. REGS.            
                                       R P                                                LAST  LAST  LAST  LAST  LAST  # of  # of
                                       E E                                   ACCR. TOTAL    12     6     3    30     7  ACT.  CURR
STUDY                                  G N ARM                                GOAL REGS. Month Month Month  DAYS  DAYS INSTs  IRBs
-------------------------------------- - - --------------------------------- ----- ----- ----- ----- ----- ----- ----- ----- -----
S1007-Breast,Adj,N1,Endocrine+/-Chemo  1 Y 1  Recurrence Score testing        9400   544   544   447   259   103    17   400   198
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     544   544   447   259   103    17            
                                                                                                                                  
                                       2 Y 2  Chemo and Endocrine Therapy     4000   126   126   108    59    25     3   400   198
                                           3  Endocrine Therapy Alone                126   126   105    58    24     4            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     252   252   213   117    49     7            
                                                                                                                                  
                                                                                                                                  
S0500-Brst,Adv,CTC,mntain v chnge tx   1 Y 1  Initial screening blood draw     500    21     6     3     2     2     2   201    85
                                           2  < 5 CTC, Arm A (Low Risk)              268    59    30    19     8     4            
                                           3  >= 5 CTC, re-reg required               37    12     5     5     4     0            
                                           4  Maintain current therapy               222    46    20     4     1     0            
                                           5  Switch therapy                          56    11     5     2     1     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     604   134    63    32    16     6            
                                                                                                                                  
                                       2 Y 6  Maintain current therapy         120    61    17    11     4     2     0   201    85
                                           7  Switch therapy                          56    13     5     2     2     2            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     117    30    16     6     4     2            
                                                                                                                                  
                                                                                                                                  
S0800-Brst,Neoadj nabPAC+/-Bev->AC+G   1 Y 1  Nab-PAC + BEV -> AC+PEG-G        200    57    44    23     9     0     0   220    86
                                           2  Nab-PAC -> AC + PEG-G                   33    20    15     8     4     1            
                                           3  AC + PEG-G -> Nab-PAC                   33    24    14     6     3     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     123    88    52    23     7     1            
                                                                                                                                  
                                                                                                                                  
B39-Stg 0-2, whole vs partial RT       1 E Total Registrations                        14     0     0     0     0     0   300   133
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      14     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
B47-Chemo vs Chemo + Trastuzumab       1 E Total Registrations                        15    15     9     4     1     0   314   152
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      15    15     9     4     1     0            
                                                                                                                                  
                                                                                                                                  
C40101-Breast, Adj, Node neg, AC vs T  1 E Total Registrations                       733     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     733     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
C40302-Endocrine +/1 Inhibition        1 E Total Registrations                        28     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      28     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
C40503-EndocrineTxCombo w/AntiVEGF Tx  1 E Total Registrations                        39    20     4     0     0     0   172    79
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      39    20     4     0     0     0            
                                                                                                                                  
                                                                                                                                  
C40601-NeoAdj, Her-2+, Pac+Trast or La 1 E Total Registrations                        30    22    14     9     7     2   151    83
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      30    22    14     9     7     2            
                                                                                                                                  
                                                                                                                                  
C40603-Carb/Bev+Neoadj Pac, then AC/EC 1 E Total Registrations                        35    25     9     1     0     0   198   104
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      35    25     9     1     0     0            
                                                                                                                                  
                                                                                                                                  
C70301-QOLEmployInformCareCost Analysi 1 E Total Registrations                        35     0     0     0     0     0           1
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      35     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
E1105-Adv, Trastuzumab +/- Bev         1 E Total Registrations                        15     0     0     0     0     0   102    26
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      15     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
E2108-Early Local Tx for Int Prim Tum  1 E Total Registrations                         3     3     2     1     1     0          83
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       3     3     2     1     1     0            
                                                                                                                                  
                                                                                                                                  
                                                                 

                                                                                                                             
03 FEB 2012 05:50                    BREAST ACCRUAL REPORT - OPEN and recently closed STUDIES                                     
                                                                                                                                  
                                         O                                               REGS. REGS. REGS. REGS. REGS.            
                                       R P                                                LAST  LAST  LAST  LAST  LAST  # of  # of
                                       E E                                   ACCR. TOTAL    12     6     3    30     7  ACT.  CURR
STUDY                                  G N ARM                                GOAL REGS. Month Month Month  DAYS  DAYS INSTs  IRBs
-------------------------------------- - - --------------------------------- ----- ----- ----- ----- ----- ----- ----- ----- -----
E3108-CYP2D6 Activity&SingleAgTamox    1 E Total Registrations                         5     5     5     3     2     1   124    49
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       5     5     5     3     2     1            
                                                                                                                                  
                                                                                                                                  
IBC24-02-Ovar Ftn suppress/premeno     1 E Total Registrations                       187     0     0     0     0     0   234    99
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     187     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
JMA20-Breast, Early, Regional RT       1 E Total Registrations                         8     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       8     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
JMA27B-5yr Adj Anast vs Exemestrane    1 E Total Registrations                        94     0     0     0     0     0    36    10
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      94     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
MA32-Metformn vs Placebo               1 E Total Registrations                       250   250   219    98    43    10         106
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     250   250   219    98    43    10            
                                                                                                                                  
                                                                                                                                  
N0434-JMA27 Companion Study            1 E Total Registrations                       100     0     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     100     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
N063D-ALTTO                            1 E Total Registrations                       119    22     0     0     0     0   278   116
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                     119    22     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
N0733-Her2+, Cap + Lap +/- IMC-A12     1 E Total Registrations                         5     2     2     1     1     1   186    76
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                       5     2     2     1     1     1            
                                                                                                                                  
                                                                                                                                  
PACCT-1-Assess of Ca Clinical Tests    1 E Total Registrations                      1712     0     0     0     0     0   410   202
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                    1712     0     0     0     0     0            
                                                                                                                                  
                                                                                                                                  
Z1071-Node+, chemo + LN dissect        1 E Total Registrations                        67    32     0     0     0     0            
                                                                                   ----- ----- ----- ----- ----- -----            
                                                                                      67    32     0     0     0     0            
                                                                                                                                  
                                                                                                                                  































                                                                 

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