Table 1
| SWOG/ Support |
STUDY | R E G |
O P E N |
ARM | ACCR. GOAL |
TOTAL REGS. |
REGS. LAST 12 Month |
REGS. LAST 6 Month |
REGS. LAST 3 Month |
REGS. LAST 30 DAYS |
REGS. LAST 7 DAYS |
DATE OF FIRST REG. |
# of ACT. INSTs |
# of CURR IRBs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SWOG | S1007-Breast,Adj,N1,Endocrine+/-Chemo | 1 | Y | 1 Recurrence Score testing | 9400 | 9252 | 799 | 420 | 203 | 68 | 16 | 02/28/2011 | 408 | 206 |
| 9252 | 799 | 420 | 203 | 68 | 16 | |||||||||
| 2 | Y | 2 Chemo and Endocrine Therapy | 4000 | 2493 | 272 | 138 | 71 | 22 | 6 | 02/28/2011 | ||||
| 3 Endocrine Therapy Alone | 2483 | 276 | 145 | 71 | 21 | 7 | ||||||||
| 4976 | 548 | 283 | 142 | 43 | 13 | |||||||||
| S1207-Brst,Adj,Endocrine+/-Everolimus | 1 | Y | 1 Blinded drug + Endocrine | 1900 | 647 | 222 | 114 | 53 | 18 | 7 | 09/12/2013 | 485 | 248 | |
| 2 Blinded drug + Endocrine | 641 | 213 | 111 | 50 | 17 | 4 | ||||||||
| 1288 | 435 | 225 | 103 | 35 | 11 | |||||||||
| S1222-Brst,Fulv. +/- Ever. +/- Anastr. | 1 | T | 1 Blinded treatment | 840 | 12 | 0 | 0 | 0 | 0 | 0 | 05/15/2014 | 17 | 6 | |
| 2 Blinded treatment | 12 | 0 | 0 | 0 | 0 | 0 | ||||||||
| 3 Blinded treatment | 13 | 0 | 0 | 0 | 0 | 0 | ||||||||
| 37 | 0 | 0 | 0 | 0 | 0 | |||||||||
| S1416-Brst, TNBC/BRCA, Cis+/- ABT-888 | 1 | Y | 1 Blinded Drug + Cisplatin | 333 | 56 | 56 | 44 | 22 | 7 | 2 | 09/15/2016 | 267 | 124 | |
| 2 Blinded Drug + Cisplatin | 56 | 56 | 45 | 25 | 8 | 3 | ||||||||
| 112 | 112 | 89 | 47 | 15 | 5 | |||||||||
| S1418-Breast, Adj, TNBC, MK-3475 (Pembrolizumab) | 1 | Y | 1 Tissue for PD-L1 testing | 1000 | 49 | 49 | 47 | 32 | 11 | 2 | 01/18/2017 | 366 | 149 | |
| 49 | 49 | 47 | 32 | 11 | 2 | |||||||||
| 2 | Y | 2 Observation | 1000 | 22 | 22 | 22 | 18 | 6 | 3 | 01/18/2017 | ||||
| 3 MK-3475 (Pembrolizumab) | 19 | 19 | 19 | 13 | 3 | 1 | ||||||||
| 41 | 41 | 41 | 31 | 9 | 4 | |||||||||
| Yes | A011106-Breast, Neoadj, ALTERNATE study | 1 | E | Total Registrations | 41 | 21 | 11 | 7 | 3 | 1 | 04/29/2014 | 267 | 126 | |
| 41 | 21 | 11 | 7 | 3 | 1 | |||||||||
| E1Z11-Brst,Genetic Predictors of AIMSS | 1 | E | Total Registrations | 142 | 9 | 4 | 3 | 0 | 0 | 08/13/2013 | 270 | 95 | ||
| 142 | 9 | 4 | 3 | 0 | 0 | |||||||||
| No | A011202-Breast, Nodal XRT +/- ALND | 0 | E | Total Registrations | 126 | 47 | 29 | 15 | 4 | 2 | 03/20/2014 | 333 | 175 | |
| 126 | 47 | 29 | 15 | 4 | 2 | |||||||||
| 1 | E | Total Registrations | 51 | 18 | 10 | 5 | 1 | 0 | 03/20/2014 | |||||
| 51 | 18 | 10 | 5 | 1 | 0 | |||||||||
| A011203-Breast, Adv, Tam vs Endoxifen | 0 | E | Total Registrations | 9 | 1 | 1 | 0 | 0 | 0 | 08/14/2015 | 242 | 90 | ||
| 9 | 1 | 1 | 0 | 0 | 0 | |||||||||
| 1 | E | Total Registrations | 7 | 1 | 1 | 0 | 0 | 0 | 08/14/2015 | |||||
| 7 | 1 | 1 | 0 | 0 | 0 | |||||||||
| 2 | E | Total Registrations | 2 | 0 | 0 | 0 | 0 | 0 | 08/14/2015 | |||||
| 2 | 0 | 0 | 0 | 0 | 0 | |||||||||
| A011401-Breast, adj, Stage II/III HER2-, weight loss | 1 | E | Total Registrations | 57 | 57 | 46 | 29 | 12 | 2 | 10/05/2016 | 261 | 147 | ||
| 57 | 57 | 46 | 29 | 12 | 2 | |||||||||
| 2 | E | Total Registrations | 46 | 46 | 36 | 23 | 13 | 3 | 10/05/2016 | |||||
| 46 | 46 | 36 | 23 | 13 | 3 | |||||||||
| B51-Breast, Regional Nodal XRT | 1 | E | Total Registrations | 15 | 7 | 6 | 3 | 1 | 0 | 06/13/2014 | 435 | 218 | ||
| 15 | 7 | 6 | 3 | 1 | 0 | |||||||||
| B55-Brst, Adj Olaparib for BRCA,TNBC | 1 | E | Total Registrations | 41 | 20 | 10 | 4 | 0 | 0 | 12/15/2014 | 422 | 194 | ||
| 41 | 20 | 10 | 4 | 0 | 0 | |||||||||
| 2 | E | Total Registrations | 18 | 9 | 7 | 3 | 0 | 0 | 12/15/2014 | |||||
| 18 | 9 | 7 | 3 | 0 | 0 | |||||||||
| E2112-Brst,Adv,Exemestane+/-Entinostat | 1 | E | Total Registrations | 35 | 18 | 9 | 5 | 1 | 0 | 04/01/2015 | 296 | 165 | ||
| 35 | 18 | 9 | 5 | 1 | 0 | |||||||||
| EA1131-Brst, TNBC, Post-op Chemo vs Obs | 0 | E | Total Registrations | 11 | 7 | 6 | 4 | 1 | 0 | 11/12/2015 | 294 | 127 | ||
| 11 | 7 | 6 | 4 | 1 | 0 | |||||||||
| 1 | P | Total Registrations | 4 | 3 | 3 | 3 | 2 | 0 | 11/12/2015 | |||||
| 4 | 3 | 3 | 3 | 2 | 0 | |||||||||
| NRGBR003-Brst,Adj,TNBC,AC -> WP +/- Carbo | 1 | E | Total Registrations | 38 | 22 | 12 | 10 | 2 | 0 | 10/16/2015 | 441 | 217 | ||
| 38 | 22 | 12 | 10 | 2 | 0 | |||||||||