Table 1
| SWOG/ Support |
STUDY | R E G |
O P E N |
ARM | ACCR. GOAL |
TOTAL REGS. |
REGS. LAST 12 Month |
REGS. LAST 6 Month |
REGS. LAST 3 Month |
REGS. LAST 30 DAYS |
REGS. LAST 7 DAYS |
DATE OF FIRST REG. |
# of ACT. INSTs |
# of CURR IRBs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SWOG | S1007-Breast,Adj,N1,Endocrine+/-Chemo | 1 | Y | 1 Recurrence Score testing | 9400 | 9365 | 777 | 378 | 172 | 66 | 15 | 02/28/2011 | 413 | 205 |
| 9365 | 777 | 378 | 172 | 66 | 15 | |||||||||
| 2 | Y | 2 Chemo and Endocrine Therapy | 4000 | 2529 | 257 | 128 | 57 | 17 | 5 | 02/28/2011 | ||||
| 3 Endocrine Therapy Alone | 2518 | 258 | 124 | 55 | 20 | 5 | ||||||||
| 5047 | 515 | 252 | 112 | 37 | 10 | |||||||||
| S1207-Brst,Adj,Endocrine+/-Everolimus | 1 | Y | 1 Blinded drug + Endocrine | 1900 | 677 | 213 | 106 | 45 | 18 | 5 | 09/12/2013 | 458 | 239 | |
| 2 Blinded drug + Endocrine | 679 | 217 | 106 | 53 | 23 | 2 | ||||||||
| 1356 | 430 | 212 | 98 | 41 | 7 | |||||||||
| S1222-Brst,Fulv. +/- Ever. +/- Anastr. | 1 | T | 1 Blinded treatment | 840 | 12 | 0 | 0 | 0 | 0 | 0 | 05/15/2014 | 16 | 6 | |
| 2 Blinded treatment | 12 | 0 | 0 | 0 | 0 | 0 | ||||||||
| 3 Blinded treatment | 13 | 0 | 0 | 0 | 0 | 0 | ||||||||
| 37 | 0 | 0 | 0 | 0 | 0 | |||||||||
| S1416-Brst, TNBC/BRCA, Cis+/- ABT-888 | 1 | Y | 1 Blinded Drug + Cisplatin | 333 | 69 | 69 | 41 | 19 | 8 | 1 | 09/15/2016 | 264 | 124 | |
| 2 Blinded Drug + Cisplatin | 66 | 64 | 43 | 16 | 5 | 1 | ||||||||
| 135 | 133 | 84 | 35 | 13 | 2 | |||||||||
| S1418-Breast, Adj, TNBC, MK-3475 (Pembrolizumab) | 1 | Y | 1 Tissue for PD-L1 testing | 1000 | 81 | 81 | 70 | 43 | 20 | 4 | 01/18/2017 | 382 | 165 | |
| 81 | 81 | 70 | 43 | 20 | 4 | |||||||||
| 2 | Y | 2 Observation | 1000 | 32 | 32 | 30 | 16 | 8 | 0 | 01/18/2017 | ||||
| 3 MK-3475 (Pembrolizumab) | 34 | 34 | 31 | 18 | 7 | 2 | ||||||||
| 66 | 66 | 61 | 34 | 15 | 2 | |||||||||
| Yes | A011106-Breast, Neoadj, ALTERNATE study | 1 | E | Total Registrations | 49 | 26 | 16 | 11 | 5 | 2 | 04/29/2014 | 249 | 115 | |
| 49 | 26 | 16 | 11 | 5 | 2 | |||||||||
| E1Z11-Brst,Genetic Predictors of AIMSS | 1 | E | Total Registrations | 144 | 8 | 6 | 2 | 0 | 0 | 08/13/2013 | 259 | 86 | ||
| 144 | 8 | 6 | 2 | 0 | 0 | |||||||||
| No | A011202-Breast, Nodal XRT +/- ALND | 0 | E | Total Registrations | 137 | 54 | 30 | 14 | 7 | 1 | 03/20/2014 | 338 | 179 | |
| 137 | 54 | 30 | 14 | 7 | 1 | |||||||||
| 1 | E | Total Registrations | 54 | 19 | 9 | 4 | 2 | 0 | 03/20/2014 | |||||
| 54 | 19 | 9 | 4 | 2 | 0 | |||||||||
| A011401-Breast, adj, Stage II/III HER2-, weight loss | 1 | E | Total Registrations | 74 | 74 | 51 | 26 | 6 | 2 | 10/05/2016 | 403 | 220 | ||
| 74 | 74 | 51 | 26 | 6 | 2 | |||||||||
| 2 | E | Total Registrations | 62 | 62 | 43 | 29 | 5 | 0 | 10/05/2016 | |||||
| 62 | 62 | 43 | 29 | 5 | 0 | |||||||||
| A011502-Brst, Adj, Nodal+&HER2-, Aspirin vs. Placebo | 1 | E | Total Registrations | 14 | 14 | 13 | 9 | 2 | 0 | 03/20/2017 | 190 | |||
| 14 | 14 | 13 | 9 | 2 | 0 | |||||||||
| A221405-Breast, ET interruption, Pregnancy Outcomes | 1 | E | Total Registrations | 2 | 2 | 2 | 0 | 0 | 0 | 05/08/2017 | 14 | |||
| 2 | 2 | 2 | 0 | 0 | 0 | |||||||||
| B51-Breast, Regional Nodal XRT | 1 | E | Total Registrations | 18 | 10 | 6 | 4 | 1 | 0 | 06/13/2014 | 417 | 216 | ||
| 18 | 10 | 6 | 4 | 1 | 0 | |||||||||
| B55-Brst, Adj Olaparib for BRCA,TNBC | 1 | E | Total Registrations | 43 | 20 | 6 | 2 | 2 | 1 | 12/15/2014 | 409 | 181 | ||
| 43 | 20 | 6 | 2 | 2 | 1 | |||||||||
| 2 | E | Total Registrations | 18 | 8 | 3 | 0 | 0 | 0 | 12/15/2014 | |||||
| 18 | 8 | 3 | 0 | 0 | 0 | |||||||||
| E2112-Brst,Adv,Exemestane+/-Entinostat | 1 | E | Total Registrations | 39 | 17 | 10 | 4 | 1 | 0 | 04/01/2015 | 289 | 167 | ||
| 39 | 17 | 10 | 4 | 1 | 0 | |||||||||
| EA1131-Brst, TNBC, Post-op Chemo vs Obs | 0 | E | Total Registrations | 14 | 9 | 8 | 4 | 1 | 1 | 11/12/2015 | 300 | 123 | ||
| 14 | 9 | 8 | 4 | 1 | 1 | |||||||||
| 1 | P | Total Registrations | 6 | 5 | 5 | 4 | 1 | 0 | 11/12/2015 | |||||
| 6 | 5 | 5 | 4 | 1 | 0 | |||||||||
| NRGBR003-Brst,Adj,TNBC,AC -> WP +/- Carbo | 1 | E | Total Registrations | 42 | 21 | 15 | 5 | 3 | 2 | 10/16/2015 | 422 | 216 | ||
| 42 | 21 | 15 | 5 | 3 | 2 | |||||||||